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PRMT3 belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts on 40S ribosomal protein S2 (rpS2), which is its major in-vivo substrate, and is involved in the proper maturation of the 80S ribosome. Alternative splicing results in multiple transcript variants.
Gene Name: | protein arginine methyltransferase 3 |
Synonyms: | PRMT3, Arginine N-methyltransferase 3, HRMT1L3 |
Target Sequences: | AF059531 AAC39837.1 O60678 |
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