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Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation.
Gene Name: | protein arginine methyltransferase 2 |
Synonyms: | PRMT2, HMT1, HRMT1L1, PRMT2 alpha, PRMT2 beta, Arginine N-methyltransferase 2, PRMT2 gamma |
Target Sequences: | NM_001535 NP_001526.2 P55345 |
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