PRKRA / PACT

protein kinase, interferon-inducible double stranded RNA dependent activator

Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner.

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Products

Proteins (11)

Type

Over-Expression Lysate (6)

Recombinant (5)

Target

PRKRA / PACT (11)

Publications

No (11)

Tag

10His, N-terminus + Myc, C-terminus (1)

GST (1)

GST, N-terminus (1)

His (1)

Myc-DDK (Flag) (7)

Species

Bovine (1)

Human (7)

Source

293T Cells (3)

E. coli (2)

HEK 293 Cells (4)

Wheat Germ Extract (2)

Purification

Purified (3)

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Bovine PRKRA / PACT Protein (Recombinant 10His, N-terminus + Myc, C-terminus) (Full Length) - LS-G137353

Source:

E. coli

Tag:

10His, N-terminus + Myc, C-terminus

Molecular Weight:

39.4 kDa

Price:

20 µg/$405; 1 mg/$1,679; 100 µg/$598

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PRKRA / PACT Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G125815

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

32.9 kDa

Price:

100 µg/$494

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PRKRA / PACT Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G125816

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

34.4 kDa

Price:

100 µg/$494

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Human PRKRA / PACT Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89188

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

32.9 kDa

Price:

20 µg/$150

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Human PRKRA / PACT Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89189

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

34.4 kDa

Price:

20 µg/$150

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Human PRKRA / PACT Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89190

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

34.2 kDa

Price:

20 µg/$150

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Human PRKRA / PACT Protein (Recombinant GST) (Full Length) - LS-G31223

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

60.17 kDa

Price:

10 µg/$479; 25 µg/$670

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Human PRKRA / PACT Protein (Recombinant His) - LS-G2988

Source:

E. coli

Tag:

His

Price:

50 µg/$411; 250 µg/$985; 10 µg/$276

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Human PRKRA / PACT Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71205

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

34.2 kDa

Price:

20 µg/$1,107

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Human PRKRA / PACT Protein (Recombinant GST, N-terminus) (aa101-200) - LS-G60789

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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PRKRA / PACT Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100105

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

34.2 kDa

Price:

100 µg/$494

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