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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
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PRKD2 / PKD2

protein kinase D2

Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion. May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. In response to oxidative stress, is phosphorylated at Tyr-438 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B. In response to the activation of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus, phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77. Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the nucleus and is required for interleukin-2 (IL2) promoter up-regulation. During adaptive immune responses, is required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR engagement and for optimal induction of antibody responses to antigens. In epithelial cells stimulated with lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway. During TCR-induced T-cell activation, interacts with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription factors. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the basolateral membrane. Plays an important role in endothelial cell proliferation and migration prior to angiogenesis, partly through modulation of the expression of KDR/VEGFR2 and FGFR1, two key growth factor receptors involved in angiogenesis. In secretory pathway, is required for the release of chromogranin-A (CHGA)-containing secretory granules from the TGN. Downstream of PRKCA, plays important roles in angiotensin-2-induced monocyte adhesion to endothelial cells. Plays a regulatory role in angiogenesis and tumor growth by phosphorylating a downstream mediator CIB1 isoform 2, resulting in vascular endothelial growth factor A (VEGFA) secretion.

Gene Name: protein kinase D2
Family/Subfamily: Protein Kinase , PKD
Synonyms: PRKD2, HSPC187, NPKC-D2, Protein kinase D2, DKFZP586E0820
Target Sequences: NM_016457 NP_057541.2 Q9BZL6


PRKD2 / PKD2 Antibody - Brain, Glioblastoma
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Cancer
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Rabbit Polyclonal to Human PRKD2 / PKD2
ELISA, IHC, IHC-P
Unconjugated
50µg   50µl   1mg/ml   $425.00
PRKD2 / PKD2 Antibody - Anti-PRKD2 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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Mouse Monoclonal [clone 2E4] (IgG2b,k) to Human PRKD2 / PKD2
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg   $545.00
PRKD2 / PKD2 Antibody - Anti-PRKD2 antibody IHC of human brain cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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Rabbit Polyclonal (IgG) to Human PRKD2 / PKD2
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $425.00
PRKD2 / PKD2 Antibody - Anti-PRKD2 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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Rabbit Polyclonal (IgG) to Human PRKD2 / PKD2
Human
IHC, IHC-P, WB
Unconjugated
50µl   $425.00
PRKD2 / PKD2 Antibody - Anti-PRKD2 antibody IHC of human stomach. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 0.5 ug/ml.
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Rabbit Polyclonal to Human PRKD2 / PKD2
Human, Monkey
IHC, IHC-P
Unconjugated
50µg   50µl   1mg/ml   $425.00
PRKD2 / PKD2 Antibody - Anti-PRKD2 antibody IHC of human stomach. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 0.5 ug/ml.
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Rabbit Polyclonal to Human PRKD2 / PKD2
Human, Monkey
IHC, IHC-P
Biotin Conjugated
100µl   $650.00
PRKD2 / PKD2 Antibody - Anti-PRKD2 antibody IHC of human stomach. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 0.5 ug/ml.
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Rabbit Polyclonal to Human PRKD2 / PKD2
Human, Monkey
IHC, IHC-P
FITC Conjugated
100µl   $650.00
PRKD2 / PKD2 Antibody - Anti-PRKD2 antibody IHC of human stomach. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 0.5 ug/ml.
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Rabbit Polyclonal to Human PRKD2 / PKD2
Human, Monkey
IHC, IHC-P
APC Conjugated
100µl   $650.00
PRKD2 / PKD2 Antibody - Anti-PRKD2 antibody IHC of human stomach. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 0.5 ug/ml.
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Rabbit Polyclonal to Human PRKD2 / PKD2
Human, Monkey
IHC, IHC-P
AP Conjugated
100µl   $650.00
PRKD2 / PKD2 Antibody - Anti-PRKD2 antibody IHC of human stomach. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 0.5 ug/ml.
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Rabbit Polyclonal to Human PRKD2 / PKD2
Human, Monkey
IHC, IHC-P
PE Conjugated
100µl   $650.00
PRKD2 / PKD2 Antibody - Anti-PRKD2 antibody IHC of human stomach. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 0.5 ug/ml.
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Rabbit Polyclonal to Human PRKD2 / PKD2
Human, Monkey
IHC, IHC-P
HRP Conjugated, Azide-free
100µl   $650.00
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Rabbit Polyclonal (IgG) to Human PRKD2 / PKD2
Human
ELISA, IHC, WB
Biotin Conjugated
200µl   $740.00
PRKD2 / PKD2 Antibody - Western blot of Phospho-PKD2 (S876) antibody
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Rabbit Polyclonal (IgG) to Human PRKD2 / PKD2
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
PRKD2 / PKD2 Antibody - Immunohistochemical staining of paraffin-embedded Human Kidney tissue using anti-PRKD2 mouse monoclonal antibody. (Dilution 1:50).
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Mouse Monoclonal [clone OTI5G1] (IgG2b) to Human PRKD2 / PKD2
Flo, IF, IHC, IHC-P, WB
Unconjugated
100µl   0.72mg/ml   $345.00
PRKD2 / PKD2 Antibody - Immunohistochemical staining of paraffin-embedded Human Kidney tissue using anti-PRKD2 mouse monoclonal antibody. (Dilution 1:50).
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Mouse Monoclonal [clone OTI5G1] (IgG2b) to Human PRKD2 / PKD2
Dog, Rat, Human, Monkey
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100µg   $395.00
PRKD2 / PKD2 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PRKD2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PRKD2.
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Mouse Monoclonal [clone OTI3A1] (IgG2b) to Human PRKD2 / PKD2
Human
Flo, WB
Unconjugated
100µl   0.58mg/ml   $345.00
PRKD2 / PKD2 Antibody - Immunohistochemical analysis of PRKD2 (pS876) staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP-conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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Rabbit Polyclonal to Human PRKD2 / PKD2
Human
IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $265.00
PRKD2 / PKD2 Antibody - IHC of paraffin-embedded Carcinoma of Human bladder tissue using anti-PRKD2 mouse monoclonal antibody.
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Mouse Monoclonal [clone OTI5A3] (IgG2b) to Human PRKD2 / PKD2
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100µl   0.97mg/ml   $345.00
PRKD2 / PKD2 Antibody - IHC of paraffin-embedded Carcinoma of Human bladder tissue using anti-PRKD2 mouse monoclonal antibody.
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Mouse Monoclonal [clone OTI5A3] (IgG2b) to Human PRKD2 / PKD2
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100µg   $395.00
PRKD2 / PKD2 Antibody - IHC of paraffin-embedded Carcinoma of Human pancreas tissue using anti-PRKD2 mouse monoclonal antibody. (Dilution 1:50).
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Mouse Monoclonal [clone OTI4F1] (IgG2a) to Human PRKD2 / PKD2
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100µl   0.89mg/ml   $345.00
PRKD2 / PKD2 Antibody - IHC of paraffin-embedded Carcinoma of Human pancreas tissue using anti-PRKD2 mouse monoclonal antibody. (Dilution 1:50).
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Mouse Monoclonal [clone OTI4F1] (IgG2a) to Human PRKD2 / PKD2
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100µg   $395.00
PRKD2 / PKD2 Antibody - Anti-PRKD2 mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PRKD2.
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Mouse Monoclonal [clone OTI3B12] (IgG1) to Human PRKD2 / PKD2
Flo, IF, WB
Unconjugated
100µl   1mg/ml   $345.00
PRKD2 / PKD2 Antibody - Anti-PRKD2 mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PRKD2.
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Mouse Monoclonal [clone OTI3B12] (IgG1) to Human PRKD2 / PKD2
Dog, Rat, Human, Monkey
Flo, IF, WB
Unconjugated, Carrier-free
100µg   $395.00
PRKD2 / PKD2 Antibody - Immunofluorescence staining of PRKD2 in Hela cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS, blocked with 10% serum, and incubated with rabbit anti-Human PRKD2 polyclonal antibody (dilution ratio 1:1000) at 4°C overnight. Then cells were stained with the Alexa Fluor 488-conjugated Goat Anti-rabbit IgG secondary antibody (green). Positive staining was localized to cytoplasm and nucleus.
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Rabbit Polyclonal (IgG) to Human PRKD2 / PKD2
Human
ELISA, ICC, IF, IP, WB
Unconjugated, Preservative Free
50µl   $235.00; 100µl   $275.00; 200µl   $305.00
PRKD2 / PKD2 Antibody - Anti-PRKD2 mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PRKD2.
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Mouse Monoclonal [clone OTI3F7] (IgG1) to Human PRKD2 / PKD2
Dog, Rat, Human, Monkey
Flo, IF, WB
Unconjugated
100µl   0.88mg/ml   $345.00
Viewing 1-25 of 87 products



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).