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Immunohistochemistry Services

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PRKD2 / PKD2

protein kinase D2

Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion. May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. In response to oxidative stress, is phosphorylated at Tyr-438 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B. In response to the activation of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus, phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77. Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the nucleus and is required for interleukin-2 (IL2) promoter up-regulation. During adaptive immune responses, is required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR engagement and for optimal induction of antibody responses to antigens. In epithelial cells stimulated with lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway. During TCR-induced T-cell activation, interacts with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription factors. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the basolateral membrane. Plays an important role in endothelial cell proliferation and migration prior to angiogenesis, partly through modulation of the expression of KDR/VEGFR2 and FGFR1, two key growth factor receptors involved in angiogenesis. In secretory pathway, is required for the release of chromogranin-A (CHGA)-containing secretory granules from the TGN. Downstream of PRKCA, plays important roles in angiotensin-2-induced monocyte adhesion to endothelial cells. Plays a regulatory role in angiogenesis and tumor growth by phosphorylating a downstream mediator CIB1 isoform 2, resulting in vascular endothelial growth factor A (VEGFA) secretion.

Gene Name: protein kinase D2
Family/Subfamily: Protein Kinase , PKD
Synonyms: PRKD2, HSPC187, NPKC-D2, Protein kinase D2, DKFZP586E0820
Target Sequences: NM_016457 NP_057541.2 Q9BZL6

Filtered by: None
Target
PRKD2 / PKD2 (83)
Reactivity
Human (73)
Mouse (22)
Rat (15)
Dog (5)
Horse (1)
Monkey (11)
Opossum (1)
Application
IHC (38)
IHC-P (16)
WB (67)
Flo (14)
ELISA (25)
IF (14)
IP (3)
Peptide-ELISA (3)
Host
rabbit (68)
mouse (15)
Isotype
Ig (1)
IgG (35)
IgG1 (4)
IgG2a (4)
IgG2b (6)
IgG2b,k (1)
Clonality
monoclonal mc (15)
polyclonal pc (68)
Clone
2E4 (1)
OTI2E2 (2)
OTI3A1 (2)
OTI3B12 (2)
OTI3F7 (2)
OTI4F1 (2)
OTI5A3 (2)
OTI5G1 (2)
Format
AP Conjugated (4)
APC (2)
APC Conjugated (6)
Azide-free (3)
Biotin Conjugated (6)
Carrier-free (7)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (6)
HRP Conjugated (6)
PE Conjugated (6)
Unconjugated (45)
Epitope
Internal (15)
pSer876 (9)
aa327-539 (8)
aa621-832 (8)
aa937-968 (7)
810-890 aa (2)
aa825-C-term (2)
Ala872 (1)
C-Terminus (1)
aa170-210 (1)
aa320-400 (1)
aa827-876 (1)
aa829-878 (1)
aa850-865 (1)
Publications
No (83)
Showing 1-25 of 83 results

IHC-plus™ PRKD2 / PKD2 Antibody (Internal) LS-A7515
Rabbit Polyclonal to Human PRKD2 / PKD2
Human, Monkey
IHC, IHC-P
Unconjugated
50µg 50µl 1mg/ml  $425.00
Anti-PRKD2 antibody IHC of human stomach. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 0.5 ug/ml.
Anti-PRKD2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 0.5 ug/ml.

IHC-plus™ PRKD2 / PKD2 Antibody (Internal, Biotin) LS-A107077
Rabbit Polyclonal to Human PRKD2 / PKD2
Human, Monkey
IHC, IHC-P
Biotin Conjugated
100µl  $650.00
Anti-PRKD2 antibody IHC of human stomach. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 0.5 ug/ml.
Anti-PRKD2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 0.5 ug/ml.

IHC-plus™ PRKD2 / PKD2 Antibody (Internal, FITC) LS-A107078
Rabbit Polyclonal to Human PRKD2 / PKD2
Human, Monkey
IHC, IHC-P
FITC Conjugated
100µl  $650.00
Anti-PRKD2 antibody IHC of human stomach. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 0.5 ug/ml.
Anti-PRKD2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 0.5 ug/ml.

IHC-plus™ PRKD2 / PKD2 Antibody (Internal, APC) LS-A107076
Rabbit Polyclonal to Human PRKD2 / PKD2
Human, Monkey
IHC, IHC-P
APC Conjugated
100µl  $650.00
Anti-PRKD2 antibody IHC of human stomach. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 0.5 ug/ml.
Anti-PRKD2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 0.5 ug/ml.

IHC-plus™ PRKD2 / PKD2 Antibody (Internal, PE) LS-A107080
Rabbit Polyclonal to Human PRKD2 / PKD2
Human, Monkey
IHC, IHC-P
PE Conjugated
100µl  $650.00
Anti-PRKD2 antibody IHC of human stomach. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 0.5 ug/ml.
Anti-PRKD2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 0.5 ug/ml.

IHC-plus™ PRKD2 / PKD2 Antibody (clone 2E4) LS-B5453
Mouse Monoclonal [clone 2E4] (IgG2b,k) to Human PRKD2 / PKD2
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg  $545.00
Anti-PRKD2 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Western blot of PRKD2 expression in HeLa cells with PRKD2 monoclonal antibody, clone 2E4.

PRKD2 / PKD2 Antibody (aa937-968, Biotin) LS-C245450
Rabbit Polyclonal (IgG) to Human PRKD2 / PKD2
Human
ELISA, IHC, WB
Biotin Conjugated
200µl  $740.00

PRKD2 / PKD2 Antibody (810-890 aa) LS-C380938
Rabbit Polyclonal (IgG) to Human PRKD2 / PKD2
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $265.00; 200µl 1mg/ml  $335.00
Western blot of Phospho-PKD2 (S876) antibody
Western blot of Phospho-PKD2 (S876) antibody

PRKD2 / PKD2 Antibody (clone OTI5G1) LS-C115602
Mouse Monoclonal [clone OTI5G1] (IgG2b) to Human PRKD2 / PKD2
Flo, IF, IHC, IHC-P, WB
Unconjugated
100µl 0.72mg/ml  $345.00
Immunohistochemical staining of paraffin-embedded Human Kidney tissue using anti-PRKD2 mouse monoclonal antibody. (Dilution 1:50).
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-PRKD2 mouse monoclonal antibody. (Dilution 1:50).

PRKD2 / PKD2 Antibody (clone OTI5G1, Carrier-free) LS-C785022
Mouse Monoclonal [clone OTI5G1] (IgG2b) to Human PRKD2 / PKD2
Dog, Rat, Human, Monkey
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100µg  $395.00
Immunohistochemical staining of paraffin-embedded Human Kidney tissue using anti-PRKD2 mouse monoclonal antibody. (Dilution 1:50).
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-PRKD2 mouse monoclonal antibody. (Dilution 1:50).

PRKD2 / PKD2 Antibody (clone OTI3A1) LS-C115601
Mouse Monoclonal [clone OTI3A1] (IgG2b) to Human PRKD2 / PKD2
Human
Flo, WB
Unconjugated
100µl 0.58mg/ml  $345.00
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PRKD2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PRKD2.
HEK293T cells transfected with either overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-PRKD2 antibody, and then analyzed by flow cytometry.

PRKD2 / PKD2 Antibody (phospho-Ser876) LS-C358254
Rabbit Polyclonal to Human PRKD2 / PKD2
Human
IHC, IHC-P, WB
Unconjugated
100µl 1mg/ml  $265.00
Immunohistochemical analysis of PRKD2 (pS876) staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP-conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Western blot analysis of PRKD2 (pS876) expression in HeLa (A); NIH3T3 (B) whole cell lysates.

PRKD2 / PKD2 Antibody (clone OTI5A3) LS-C115589
Mouse Monoclonal [clone OTI5A3] (IgG2b) to Human PRKD2 / PKD2
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100µl 0.97mg/ml  $345.00
IHC of paraffin-embedded Carcinoma of Human bladder tissue using anti-PRKD2 mouse monoclonal antibody.
Anti-PRKD2 mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PRKD2.

PRKD2 / PKD2 Antibody (clone OTI5A3, Carrier-free) LS-C785003
Mouse Monoclonal [clone OTI5A3] (IgG2b) to Human PRKD2 / PKD2
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100µg  $395.00
IHC of paraffin-embedded Carcinoma of Human bladder tissue using anti-PRKD2 mouse monoclonal antibody.
Anti-PRKD2 mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PRKD2.

PRKD2 / PKD2 Antibody (clone OTI4F1) LS-C115611
Mouse Monoclonal [clone OTI4F1] (IgG2a) to Human PRKD2 / PKD2
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100µl 0.89mg/ml  $345.00
IHC of paraffin-embedded Carcinoma of Human pancreas tissue using anti-PRKD2 mouse monoclonal antibody. (Dilution 1:50).
IHC of paraffin-embedded Carcinoma of Human thyroid tissue using anti-PRKD2 mouse monoclonal antibody. (Dilution 1:50).

PRKD2 / PKD2 Antibody (clone OTI4F1, Carrier-free) LS-C785031
Mouse Monoclonal [clone OTI4F1] (IgG2a) to Human PRKD2 / PKD2
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100µg  $395.00
IHC of paraffin-embedded Carcinoma of Human pancreas tissue using anti-PRKD2 mouse monoclonal antibody. (Dilution 1:50).
IHC of paraffin-embedded Carcinoma of Human thyroid tissue using anti-PRKD2 mouse monoclonal antibody. (Dilution 1:50).

IHC-plus™ PRKD2 / PKD2 Antibody (aa829-878) LS-B5654
Rabbit Polyclonal (IgG) to Human PRKD2 / PKD2
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl 1mg/ml  $425.00
Anti-PRKD2 antibody IHC of human brain cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Anti-PRKD2 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.

IHC-plus™ PRKD2 / PKD2 Antibody (aa850-865) LS-B4944
Rabbit Polyclonal (IgG) to Human PRKD2 / PKD2
Human
IHC, IHC-P, WB
Unconjugated
50µl  $425.00
Anti-PRKD2 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.

PRKD2 / PKD2 Antibody (clone OTI3B12) LS-C115679
Mouse Monoclonal [clone OTI3B12] (IgG1) to Human PRKD2 / PKD2
Flo, IF, WB
Unconjugated
100µl 1mg/ml  $345.00
Anti-PRKD2 mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PRKD2.
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PRKD2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PRKD2.

PRKD2 / PKD2 Antibody (clone OTI3B12, Carrier-free) LS-C785114
Mouse Monoclonal [clone OTI3B12] (IgG1) to Human PRKD2 / PKD2
Dog, Rat, Human, Monkey
Flo, IF, WB
Unconjugated, Carrier-free
100µg  $395.00
Anti-PRKD2 mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PRKD2.
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PRKD2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PRKD2.

PRKD2 / PKD2 Antibody (clone OTI3F7) LS-C115588
Mouse Monoclonal [clone OTI3F7] (IgG1) to Human PRKD2 / PKD2
Dog, Rat, Human, Monkey
Flo, IF, WB
Unconjugated
100µl 0.88mg/ml  $345.00
Anti-PRKD2 mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PRKD2.
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PRKD2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PRKD2.

PRKD2 / PKD2 Antibody (clone OTI3F7, Carrier-free) LS-C785001
Mouse Monoclonal [clone OTI3F7] (IgG1) to Human PRKD2 / PKD2
Dog, Rat, Human, Monkey
Flo, IF, WB
Unconjugated, Carrier-free
100µg  $395.00
Anti-PRKD2 mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PRKD2.
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PRKD2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PRKD2.

PRKD2 / PKD2 Antibody (clone OTI2E2) LS-C115567
Mouse Monoclonal [clone OTI2E2] (IgG2a) to Human PRKD2 / PKD2
Human
Flo, IF, WB
Unconjugated
100µl 0.62mg/ml  $345.00
Anti-PRKD2 mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PRKD2.
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PRKD2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PRKD2.

PRKD2 / PKD2 Antibody (clone OTI2E2, Carrier-free) LS-C784981
Mouse Monoclonal [clone OTI2E2] (IgG2a) to Human PRKD2 / PKD2
Human
Flo, IF, WB
Unconjugated, Carrier-free
100µg  $395.00
Anti-PRKD2 mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PRKD2.
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PRKD2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PRKD2.

PRKD2 / PKD2 Antibody LS-C753309
Rabbit Polyclonal (IgG) to Human PRKD2 / PKD2
Human
ELISA, IHC, IP, WB
Unconjugated
100µg  $335.00
Showing 1-25 of 83 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).