Menu
Products
Services
Research Areas
Resources
Contact Us
Distributors
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Services
Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Contact Us
LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
Phone:
866-819-4732 (Toll Free North America
206-374-1102 (International)
Fax:
866-206-6909 (Toll Free North America)
206-577-4565 (International)
How To Buy - Details about how to buy our products.
Orders@LSBio.com - To submit a new order.
Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, froforma invoice requests, or other billing issues.
Technical.Support@LSBio.com - To request technical information about an LSBio product or its applications
Sales@LSBio.com - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development.
Worldwide Distributors List - To find your local distributor if you're not within the United States.
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

PRKD1 / PKC Mu

Protein kinase D1

Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response. Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation. Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1. Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In osteoblast differentiation, mediates the bone morphogenic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2. In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling. Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation. In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents. In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines. May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor.

Gene Name: Protein kinase D1
Family/Subfamily: Protein Kinase , PKD
Synonyms: PRKD1, PKCM, Pkcmu, Protein kinase C, mu, Protein kinase D, NPKC-mu, PRKCM, Protein kinase C mu, Protein kinase D1, NPKC-D1, PKC-MU, PKD, Protein kinase C mu type
Target Sequences: NM_002742 CAA53384.1 Q15139

Viewing 1-25 of 88 items
PRKD1 / PKC Mu Antibody - Anti-PKC Mu antibody IHC of human brain, cortex neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:67.
Select
Rabbit Polyclonal (IgG) to Human PRKD1 / PKC Mu
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $425.00
PRKD1 / PKC Mu Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Rabbit Polyclonal (IgG) to Human PRKD1 / PKC Mu
ELISA, IHC, IHC-P, WB
Unconjugated
40µg   80µl   0.5mg/ml   $425.00
PRKD1 / PKC Mu Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Select
(1) Publication(s)
Rabbit Polyclonal to Human PRKD1 / PKC Mu
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400µl   $325.00
PRKD1 / PKC Mu Antibody - HEK293 lysate overexpressing Human DYKDDDDK-tagged PKD1 was used to immunoprecipitate PKD1 with 2ug antibody. The precipitate was subsequently probed in Western blot using antibody at 1ug/ml. The secondary anti-goat picks up the heavy chain of antibody used
Select
Goat Polyclonal to Human PRKD1 / PKC Mu
Human
IHC, IP, Peptide-ELISA, WB
Unconjugated
100µg   0.5mg/ml   $405.00
PRKD1 / PKC Mu Antibody - Immunohistochemistry analysis of paraffin-embedded human brain tissue, using PKD1/PKC mu Antibody. The picture on the right is blocked with the synthesized peptide.
Select
Rabbit Polyclonal (IgG) to Human PRKD1 / PKC Mu
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00
Select
Rabbit Polyclonal (IgG) to Mouse PRKD1 / PKC Mu
Mouse, Rat, Human, Monkey
ELISA, WB
Unconjugated
100µl   $575.00
PRKD1 / PKC Mu Antibody
Select
Rabbit Polyclonal (IgG) to Human PRKD1 / PKC Mu
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
PRKD1 / PKC Mu Antibody - Peptide - + Immunohistochemistry analysis of paraffin-embedded human brain tissue using PKD1/PKC µ (Ab-205) antibody.
Select
Rabbit Polyclonal (IgG) to Human PRKD1 / PKC Mu
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
100µg   $305.00
PRKD1 / PKC Mu Antibody
Select
Rabbit Polyclonal (IgG) to Human PRKD1 / PKC Mu
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
PRKD1 / PKC Mu Antibody
Select
Rabbit Polyclonal (IgG) to Human PRKD1 / PKC Mu
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
PRKD1 / PKC Mu Antibody - Western blot of PKD1 antibody
Select
Rabbit Polyclonal (IgG) to Human PRKD1 / PKC Mu
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
PRKD1 / PKC Mu Antibody - IHC of PKD1/PKC (R201) pAb in paraffin-embedded human breast tissue.
Select
Rabbit Polyclonal to Human PRKD1 / PKC Mu
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
100µl   $345.00
PRKD1 / PKC Mu Antibody - Immunohistochemistry analysis of phospho-PKD1/PKC-mu (Phospho-Ser910) antibody in paraffin-embedded human brain tissue.
Select
Rabbit Polyclonal (IgG) to Human PRKD1 / PKC Mu
Mouse, Rat, Human
ELISA, IHC, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00
PRKD1 / PKC Mu Antibody - Immunohistochemistry of paraffin-embedded Human cervical cancer using PRKD1 Polyclonal Antibody at dilution of 1:40.
Select
Rabbit Polyclonal (IgG) to Human PRKD1 / PKC Mu
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20µl   0.9mg/ml   $205.00; 60µl   0.9mg/ml   $235.00; 120µl   0.9mg/ml   $295.00; 200µl   0.9mg/ml   $395.00
PRKD1 / PKC Mu Antibody - Immunohistochemistry analysis of paraffin-embedded human heart, using PKD1/2/3/PKC mu (Phospho-Ser738+Ser742) Antibody. The picture on the right is blocked with the phospho peptide.
Select
Rabbit Polyclonal (IgG) to Human PRKD1 / PKC Mu
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00
PRKD1 / PKC Mu Antibody - Immunohistochemistry analysis of paraffin-embedded human brain, using PKD1/PKC mu (Phospho-Ser205) Antibody. The picture on the right is blocked with the phospho peptide.
Select
Rabbit Polyclonal (IgG) to Human PRKD1 / PKC Mu
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00
PRKD1 / PKC Mu Antibody - Immunohistochemistry analysis of paraffin-embedded human brain, using PKD1/PKC mu (Phospho-Tyr463) Antibody. The picture on the right is blocked with the phospho peptide.
Select
Rabbit Polyclonal (IgG) to Human PRKD1 / PKC Mu
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00
Select
Rabbit Polyclonal (IgG) to Human PRKD1 / PKC Mu
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
Select
Rabbit Polyclonal (IgG) to Human PRKD1 / PKC Mu
Mouse, Human
ELISA, IHC, WB
Unconjugated
200µl   $590.00
PRKD1 / PKC Mu Antibody
Select
Rabbit Polyclonal (IgG) to Human PRKD1 / PKC Mu
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
PRKD1 / PKC Mu Antibody - Western blot of Phospho-PKD1 (S205) antibody
Select
Rabbit Polyclonal (IgG) to Human PRKD1 / PKC Mu
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
PRKD1 / PKC Mu Antibody - Western blot of PKD1 antibody
Select
Rabbit Polyclonal (IgG) to Human PRKD1 / PKC Mu
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
PRKD1 / PKC Mu Antibody - Western blot of PKD1 antibody
Select
Rabbit Polyclonal (IgG) to Human PRKD1 / PKC Mu
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
PRKD1 / PKC Mu Antibody - P-peptide - + Immunohistochemistry analysis of paraffin-embedded human heart tissue using PKD1/2/3/PKC µ (Phospho-Ser738+Ser742) antibody.
Select
Rabbit Polyclonal (IgG) to Human PRKD1 / PKC Mu
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100µg   $305.00
PRKD1 / PKC Mu Antibody - P-peptide - + Immunohistochemistry analysis of paraffin-embedded human brain tissue using PKD1/PKC µ (Phospho-Ser205) antibody.
Select
Rabbit Polyclonal (IgG) to Human PRKD1 / PKC Mu
Mouse, Human
ELISA, IHC, WB
Unconjugated
100µg   $305.00

Viewing 1-25 of 88 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).