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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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PRKCZ / PKC-Zeta

protein kinase C, zeta

Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at 'Ser-311'. Necessary and sufficient for LTP maintenance in hippocampal CA1 pyramidal cells. In vein endothelial cells treated with the oxidant peroxynitrite, phosphorylates STK11 leading to nuclear export of STK11, subsequent inhibition of PI3K/Akt signaling, and increased apoptosis.

Gene Name: protein kinase C, zeta
Family/Subfamily: Protein Kinase , PKC
Synonyms: PRKCZ, PKC-ZETA, PKC2, Pkcz, PKCzeta, Protein kinase c zeta, Protein kinase C zeta type, NPKC-zeta, PKC Zeta, Protein kinase C, zeta, Protein kinase Czeta
Target Sequences: NM_002744 NP_002735.3 Q05513

Viewing 1-25 of 103 items
PRKCZ / PKC-Zeta Antibody - Anti-PRKCZ / PKC-Zeta antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Neuroscience
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Rabbit Polyclonal to Human PRKCZ / PKC-Zeta
Human
ELISA, IHC, IHC-P
Unconjugated
50µg   50µl   1mg/ml   $425.00
PRKCZ / PKC-Zeta Antibody - Anti-PRKCZ / PKC-Zeta antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human PRKCZ / PKC-Zeta
Human
ELISA, IHC, IHC-P
Biotin Conjugated
100µl   $650.00
PRKCZ / PKC-Zeta Antibody - Anti-PRKCZ / PKC-Zeta antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human PRKCZ / PKC-Zeta
Human
ELISA, IHC, IHC-P
FITC Conjugated
100µl   $650.00
PRKCZ / PKC-Zeta Antibody - Anti-PRKCZ / PKC-Zeta antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human PRKCZ / PKC-Zeta
Human
ELISA, IHC, IHC-P
AP Conjugated
100µl   $650.00
PRKCZ / PKC-Zeta Antibody - Anti-PRKCZ / PKC-Zeta antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human PRKCZ / PKC-Zeta
Human
ELISA, IHC, IHC-P
APC Conjugated
100µl   $650.00
PRKCZ / PKC-Zeta Antibody - Anti-PRKCZ / PKC-Zeta antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human PRKCZ / PKC-Zeta
Human
ELISA, IHC, IHC-P
HRP Conjugated, Azide-free
100µl   $650.00
PRKCZ / PKC-Zeta Antibody - Anti-PRKCZ / PKC-Zeta antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human PRKCZ / PKC-Zeta
Human
ELISA, IHC, IHC-P
PE Conjugated
100µl   $650.00
PRKCZ / PKC-Zeta Antibody - Anti-PRKCZ / PKC-Zeta antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human PRKCZ / PKC-Zeta
Human
ELISA, IHC, IHC-P
Unconjugated
50µg   1mg/ml   $425.00
PRKCZ / PKC-Zeta Antibody - Anti-PRKCZ / PKC-Zeta antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human PRKCZ / PKC-Zeta
Human
ELISA, IHC, IHC-P
Biotin Conjugated
100µl   $650.00
PRKCZ / PKC-Zeta Antibody - Anti-PRKCZ / PKC-Zeta antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human PRKCZ / PKC-Zeta
Human
ELISA, IHC, IHC-P
FITC Conjugated
100µl   $650.00
PRKCZ / PKC-Zeta Antibody - Anti-PRKCZ / PKC-Zeta antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human PRKCZ / PKC-Zeta
Human
ELISA, IHC, IHC-P
APC Conjugated
100µl   $650.00
PRKCZ / PKC-Zeta Antibody - Anti-PRKCZ / PKC-Zeta antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human PRKCZ / PKC-Zeta
Human
ELISA, IHC, IHC-P
AP Conjugated
100µl   $650.00
PRKCZ / PKC-Zeta Antibody - Anti-PRKCZ / PKC-Zeta antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human PRKCZ / PKC-Zeta
Human
ELISA, IHC, IHC-P
HRP Conjugated, Azide-free
100µl   $650.00
PRKCZ / PKC-Zeta Antibody - Anti-PRKCZ / PKC-Zeta antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human PRKCZ / PKC-Zeta
Human
ELISA, IHC, IHC-P
PE Conjugated
100µl   $650.00
PRKCZ / PKC-Zeta Antibody - Anti-PRKCZ / PKC-Zeta antibody IHC of human brain cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
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Rabbit Monoclonal [clone EP1490(2)] to Human PRKCZ / PKC-Zeta
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50µl   $425.00
PRKCZ / PKC-Zeta Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Rabbit Polyclonal (IgG) to Human PRKCZ / PKC-Zeta
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100µl   1mg/ml   $505.00
PRKCZ / PKC-Zeta Antibody - Immunohistochemical analysis of PKC zeta staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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Rabbit Polyclonal to Human PRKCZ / PKC-Zeta
Zebrafish, Rat, Rabbit, Mouse, Human, Monkey
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
100µl   1mg/ml   $245.00
PRKCZ / PKC-Zeta Antibody - IHC of p-PKC (T410) pAb in paraffin-embedded human lung carcinoma tissue.
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Rabbit Polyclonal to Human PRKCZ / PKC-Zeta
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
100µl   $345.00
PRKCZ / PKC-Zeta Antibody - Western blot of Phospho-PKC zeta (T560) antibody
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Rabbit Polyclonal (IgG) to Human PRKCZ / PKC-Zeta
Mouse, Rat, Human, Monkey
ELISA, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
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Rabbit Polyclonal to Human PRKCZ / PKC-Zeta
Mouse, Rat, Human
ELISA, IP, WB
Unconjugated
50µl   $295.00; 100µl   $375.00
PRKCZ / PKC-Zeta Antibody - 1:100 staining mouse testis tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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Rabbit Polyclonal (IgG) to Human PRKCZ / PKC-Zeta
Mouse, Rat, Human, Monkey
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
PRKCZ / PKC-Zeta Antibody - 1:100 staining human brain tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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Rabbit Polyclonal (IgG) to Human PRKCZ / PKC-Zeta
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
PRKCZ / PKC-Zeta Antibody - 1:100 staining mouse testis tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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Rabbit Polyclonal (IgG) to Human PRKCZ / PKC-Zeta
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
PRKCZ / PKC-Zeta Antibody - Peptide - + Immunohistochemistry analysis of paraffin-embedded human brain tissue using PKC ? (Ab-560) antibody.
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Rabbit Polyclonal (IgG) to Human PRKCZ / PKC-Zeta
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µg   $305.00
PRKCZ / PKC-Zeta Antibody - Peptide - + Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using PKC? (Ab-410) antibody.
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Rabbit Polyclonal (IgG) to Human PRKCZ / PKC-Zeta
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µg   100µl   1µg/µl   $305.00

Viewing 1-25 of 103 items


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).