PRKCH / PKC-Eta

protein kinase C, eta

Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis. Promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Phosphorylates ATF2 which promotes its nuclear retention and transcriptional activity and negatively regulates its mitochondrial localization.

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

PRKCH / PKC-Eta (6)

Publications

No (6)

Tag

GST (1)

GST, N-terminus (1)

GST, N-terminus + His, C-terminus (1)

His (1)

Myc-DDK (Flag) (2)

Species

Human (5)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human PRKCH / PKC-Eta Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78337

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

77.6 kDa

Price:

20 µg/$150

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Human PRKCH / PKC-Eta Protein (Recombinant GST, N-terminus + His, C-terminus) - LS-G145176

Source:

E. coli

Tag:

GST, N-terminus + His, C-terminus

Molecular Weight:

105.6 kDa

Price:

50 µg/$419

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Human PRKCH / PKC-Eta Protein (Recombinant GST) (Full Length) - LS-G29908

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

30.25 kDa

Price:

10 µg/$479; 25 µg/$670

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Human PRKCH / PKC-Eta Protein (Recombinant GST, N-terminus) (aa1-100) - LS-G59730

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

2 µg/$439

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PRKCH / PKC-Eta Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100767

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

77.6 kDa

Price:

100 µg/$494

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Human PRKCH / PKC-Eta Protein (Recombinant His) (aa355-614) - LS-G11847

Source:

E. coli

Tag:

His

Molecular Weight:

31.2 kDa

Price:

10 µg/$284; 50 µg/$460; 100 µg/$735; 200 µg/$917; 1 mg/$2,037; 500 µg/$1,571; 5 mg/$3,207; 2 mg/$2,225

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