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PRKCE / PKC-Epsilon

protein kinase C, epsilon

Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1.

Gene Name: protein kinase C, epsilon
Family/Subfamily: Protein Kinase , PKC
Synonyms: PRKCE, NPKC-epsilon, PKC epsilon, Protein kinase C epsilon, Protein kinase C epsilon type, Pkcepsilon, PKCE, Protein kinase C, epsilon
Target Sequences: NM_005400 NP_005391.1 Q02156

Publications (1)

1
Antiphospholipid Antibodies Alter Cell-Death-Regulating Lipid Metabolites in First and Third Trimester Human Placentae. Priyadarshini Pantham, Alexander E P Heazell, Graham Mullard, Paul Begley, Qi Chen, Maria Brown, Warwick B Dunn, Lawrence W Chamley. American journal of reproductive immunology (New York, N.Y. : 1989). 2015 August;74:181-99. [Full Text Article] [PubMed:25856778]

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Antibodies (67)
Primary (67)
PRKCE / PKC-Epsilon (67)
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No (67)
PRKCE / PKC-Epsilon Antibody - IHC of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-PRKCE mouse monoclonal antibody.
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PRKCE / PKC-Epsilon Mouse anti-Human Monoclonal (OTI2A12) Antibody
Dog, Human, Monkey
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
PRKCE / PKC-Epsilon Antibody - IHC of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-PRKCE mouse monoclonal antibody.
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PRKCE / PKC-Epsilon Mouse anti-Human Monoclonal (Carrier-free) (OTI2A12) Antibody
Dog, Human, Monkey
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
PRKCE / PKC-Epsilon Antibody - IHC of paraffin-embedded Carcinoma of Human pancreas tissue using anti-PRKCE mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).
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PRKCE / PKC-Epsilon Mouse anti-Human Monoclonal (OTI4G8) Antibody
Human, Monkey
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
PRKCE / PKC-Epsilon Antibody - IHC of paraffin-embedded Carcinoma of Human pancreas tissue using anti-PRKCE mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).
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PRKCE / PKC-Epsilon Mouse anti-Human Monoclonal (Carrier-free) (OTI4G8) Antibody
Human, Monkey
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
PRKCE / PKC-Epsilon Antibody - IHC of paraffin-embedded Human thyroid tissue using anti-PRKCE mouse monoclonal antibody.
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PRKCE / PKC-Epsilon Mouse anti-Human Monoclonal (OTI1B7) Antibody
Dog, Human, Monkey
Flo, IF, IHC, IHC-P
Unconjugated
100 µl/$434
PRKCE / PKC-Epsilon Antibody - IHC of paraffin-embedded Human thyroid tissue using anti-PRKCE mouse monoclonal antibody.
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PRKCE / PKC-Epsilon Mouse anti-Human Monoclonal (Carrier-free) (OTI1B7) Antibody
Dog, Human, Monkey
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
PRKCE / PKC-Epsilon Antibody - IHC of paraffin-embedded Human Kidney tissue using anti-PRKCE mouse monoclonal antibody.
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PRKCE / PKC-Epsilon Mouse anti-Human Monoclonal (OTI4B3) Antibody
Dog, Human, Monkey
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
PRKCE / PKC-Epsilon Antibody - IHC of paraffin-embedded Human Kidney tissue using anti-PRKCE mouse monoclonal antibody.
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PRKCE / PKC-Epsilon Mouse anti-Human Monoclonal (Carrier-free) (OTI4B3) Antibody
Dog, Human, Monkey
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
PRKCE / PKC-Epsilon Antibody - Anti-PRKCE mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PRKCE.
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PRKCE / PKC-Epsilon Mouse anti-Human Monoclonal (OTI2E9) Antibody
Dog, Human, Monkey
Flo, IF, WB
Unconjugated
100 µl/$434
PRKCE / PKC-Epsilon Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
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PRKCE / PKC-Epsilon Rabbit anti-Human Polyclonal (aa688-737) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100 µl/$515
PRKCE / PKC-Epsilon Antibody - IHC of paraffin-embedded Human Kidney tissue using anti-PRKCE mouse monoclonal antibody.
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PRKCE / PKC-Epsilon Mouse anti-Human Monoclonal (OTI1B4) Antibody
Dog, Human, Monkey
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
PRKCE / PKC-Epsilon Antibody - IHC of paraffin-embedded Human Kidney tissue using anti-PRKCE mouse monoclonal antibody.
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PRKCE / PKC-Epsilon Mouse anti-Human Monoclonal (Carrier-free) (OTI1B4) Antibody
Dog, Human, Monkey
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
PRKCE / PKC-Epsilon Antibody - IHC of paraffin-embedded Carcinoma of Human bladder tissue using anti-PRKCE mouse monoclonal antibody.
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PRKCE / PKC-Epsilon Mouse anti-Human Monoclonal (OTI3A12) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
100 µl/$434
PRKCE / PKC-Epsilon Antibody - IHC of paraffin-embedded Carcinoma of Human bladder tissue using anti-PRKCE mouse monoclonal antibody.
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PRKCE / PKC-Epsilon Mouse anti-Human Monoclonal (Carrier-free) (OTI3A12) Antibody
Human
Flo, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
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PRKCE / PKC-Epsilon Rabbit anti-Human Monoclonal (22B10) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$688
PRKCE / PKC-Epsilon Antibody - Immunofluorescent analysis of PKC epsilon (pS729) staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 deg C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
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PRKCE / PKC-Epsilon Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Rabbit, Mouse, Rat, Human
ICC, IF, WB
Unconjugated
30 µl/$263; 100 µl/$315; 200 µl/$379
PRKCE / PKC-Epsilon Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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PRKCE / PKC-Epsilon Rabbit anti-Human Polyclonal (aa206-236) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
PRKCE / PKC-Epsilon Antibody - PKC epsilon antibody IHC-paraffin: Mouse Intestine Tissue.
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PRKCE / PKC-Epsilon Rabbit anti-Human Polyclonal (aa53-236) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
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PRKCE / PKC-Epsilon Rabbit anti-Human Polyclonal (aa206-236) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
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PRKCE / PKC-Epsilon Rabbit anti-Human Polyclonal (670-750 aa) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
PRKCE / PKC-Epsilon Antibody - Western blot of PKC epsilon antibody
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PRKCE / PKC-Epsilon Rabbit anti-Human Polyclonal (670-750 aa) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
PRKCE / PKC-Epsilon Antibody - Peptide - + Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using PKC-pan (Ab-497) antibody.
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PRKCE / PKC-Epsilon Rabbit anti-Human Polyclonal (p729) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
PRKCE / PKC-Epsilon Antibody - Western blot of recombinant PRKCE / PKC-Epsilon.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PRKCE / PKC-Epsilon Rabbit anti-Human Polyclonal (aa403-672) Antibody
Mouse, Pig, Human
WB
Unconjugated
100 µl/$299; 200 µl/$337; 500 µl/$463; 1 ml/$527; 2 ml/$682; 5 ml/$1,141
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PRKCE / PKC-Epsilon Rabbit anti-Human Polyclonal Antibody
Human
ELISA, ICC, IHC, WB
Unconjugated
100 µg/$331
PRKCE / PKC-Epsilon Antibody - Immunohistochemistry of paraffin-embedded rat spleen using PRKCE antibody at dilution of 1:200 (x400 lens).
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PRKCE / PKC-Epsilon Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).