PRKCD / PKC-Delta

protein kinase C, delta

Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction. Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis. In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53. In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53. In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation. Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1. Is highly expressed in a number of cancer cells and promotes cell survival and resistance against chemotherapeutic drugs by inducing cyclin D1 (CCND1) and hyperphosphorylation of RB1, and via several pro-survival pathways, including NF-kappa-B, AKT1 and MAPK1/3 (ERK1/2). Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways. May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA. In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation. Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release. Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin. The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion.

☰ Filters

Products

Proteins (11)

Type

Over-Expression Lysate (4)

Recombinant (7)

Target

PRKCD / PKC-Delta (11)

Publications

No (11)

Tag

GST (1)

GST, N-terminus (1)

His (1)

His/GST,N-terminus (1)

His-T7 (2)

Myc-DDK (Flag) (5)

Species

Human (6)

Mouse (2)

Rat (1)

Source

293T Cells (2)

E. coli (3)

HEK 293 Cells (3)

Insect Cells (1)

Wheat Germ Extract (2)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (1)

Select

Mouse PRKCD / PKC-Delta Protein (Recombinant His-T7) (aa328-674) - LS-G12181

Source:

E. coli

Tag:

His-T7

Molecular Weight:

44.1 kDa

Price:

10 µg/$287; 50 µg/$480; 100 µg/$767; 200 µg/$957; 1 mg/$2,089; 500 µg/$1,617; 5 mg/$3,347; 2 mg/$2,278

Select

PRKCD / PKC-Delta Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115437

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

77.3 kDa

Price:

100 µg/$710

Select

Mouse PRKCD / PKC-Delta Protein (Recombinant His/GST,N-terminus) (Met1-Ile674) - LS-G139934

Source:

Insect Cells

Tag:

His/GST,N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

106 kDa

Price:

50 µg/$561

Select

Human PRKCD / PKC-Delta Protein (Recombinant GST) (Full Length) - LS-G29904

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

103.9 kDa

Price:

2 µg/$439

Select

Human PRKCD / PKC-Delta Protein (Recombinant His-T7) (aa330-672) - LS-G24014

Source:

E. coli

Tag:

His-T7

Molecular Weight:

43.4 kDa

Price:

10 µg/$268; 50 µg/$362; 100 µg/$577; 200 µg/$722; 1 mg/$1,755; 500 µg/$1,325; 5 mg/$2,708; 2 mg/$1,934

Select

Rat PRKCD / PKC-Delta Protein (Recombinant His) (aa347-601) - LS-G24015

Source:

E. coli

Tag:

His

Molecular Weight:

30.6 kDa

Price:

10 µg/$289; 50 µg/$490; 100 µg/$782; 200 µg/$977; 1 mg/$2,114; 500 µg/$1,640; 5 mg/$3,417; 2 mg/$2,304

Select

Human PRKCD / PKC-Delta Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66703

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

77.3 kDa

Price:

20 µg/$1,107

Select

Human PRKCD / PKC-Delta Protein (Recombinant GST, N-terminus) (aa577-676) - LS-G59728

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

Human PRKCD / PKC-Delta Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78327

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

77.3 kDa

Price:

20 µg/$150

Select

Human PRKCD / PKC-Delta Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78326

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

77.3 kDa

Price:

20 µg/$215

Select

PRKCD / PKC-Delta Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G102608

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

77.3 kDa

Price:

100 µg/$494

Viewing 1-11 of 11 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: Proteins

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.