PRKAG1 / AMPK Gamma 1

protein kinase, AMP-activated, gamma 1 non-catalytic subunit

AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.

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ELISA Kits (6)

Type

Cell-Based (1)

Custom (4)

Sandwich (1)

Target

PRKAG1 / AMPK Gamma 1 (6)

Reactivity

Human (2)

Mouse (2)

Rat (2)

Bovine (1)

Pig (1)

Format

96-Well Microplate (1)

96-Well Strip Plate (5)

Publications

No (6)

Sample Type

Adherent Cell Cultures (1)

Plasma (1)

Serum (1)

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Mouse/Human/Rat PRKAG1 / AMPK Gamma 1 (Cell-Based ELISA) ELISA Kit - LS-F3132

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

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Mouse PRKAG1 / AMPK Gamma 1 (Custom) ELISA Kit - LS-F66419

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Price:

1 Plate/$783

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Bovine PRKAG1 / AMPK Gamma 1 (Custom) ELISA Kit - LS-F66427

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Bovine

Price:

1 Plate/$783

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Human PRKAG1 / AMPK Gamma 1 (Custom) ELISA Kit - LS-F65540

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Human

Price:

1 Plate/$783

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Rat PRKAG1 / AMPK Gamma 1 (Custom) ELISA Kit - LS-F65630

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Price:

1 Plate/$783

Select

Pig PRKAG1 / AMPK Gamma 1 (Sandwich ELISA) ELISA Kit - LS-F66566

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Pig

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$929

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