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PRKAA2 / AMPK Alpha 2

protein kinase, AMP-activated, alpha 2 catalytic subunit

Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3. AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160. Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A. Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2. In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1. AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it. May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it. Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1.

Gene Name: protein kinase, AMP-activated, alpha 2 catalytic subunit
Family/Subfamily: Protein Kinase , AMPK/SNF1
Synonyms: PRKAA2, ACACA kinase, Alpha2 AMPK, AMPK alpha 2, AMPK subunit alpha-2, Acetyl-CoA carboxylase kinase, AMPK-2, AMPKa2, AMPKalpha2, Ampk alpha2, AMPK2, PRKAA, AMPK, AMPK-alpha-2 chain, HMGCR kinase
Target Sequences: NM_006252 NP_006243.2 P54646

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Antibodies (75)
Primary (75)
PRKAA2 / AMPK Alpha 2 (75)
Human (73)
Mouse (22)
Rat (21)
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IHC (24)
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WB (71)
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ELISA (39)
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rabbit (62)
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monoclonal mc (10)
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206CT5.4.2 (6)
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No (75)
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PRKAA2 / AMPK Alpha 2 Rabbit anti-Human Polyclonal (pSer175) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$379
PRKAA2 / AMPK Alpha 2 Antibody - Immunohistochemical analysis of paraffin-embedded stomach cancer tissues using PRKAA2 mouse mAb with DAB staining.
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PRKAA2 / AMPK Alpha 2 Mouse anti-Human Monoclonal (8E11H5) Antibody
Human, Monkey
ELISA, Flo, IHC, WB
Unconjugated
100 µl/$459
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PRKAA2 / AMPK Alpha 2 Rabbit anti-Human Polyclonal (aa453-483) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
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PRKAA2 / AMPK Alpha 2 Rabbit anti-Human Polyclonal (aa453-483) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
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PRKAA2 / AMPK Alpha 2 Rabbit anti-Human Polyclonal (aa453-483) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
PRKAA2 / AMPK Alpha 2 Antibody - Formalin-fixed and paraffin-embedded human skeletal muscle reacted with PRKAA2 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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PRKAA2 / AMPK Alpha 2 Rabbit anti-Human Polyclonal (aa453-483) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
PRKAA2 / AMPK Alpha 2 Antibody - IHC of paraffin-embedded A549 xenograft using AMPK alpha 2 antibody at 1:500 dilution.
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PRKAA2 / AMPK Alpha 2 Rabbit anti-Human Polyclonal (aa29-510) Antibody
Human
ICC, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$450
PRKAA2 / AMPK Alpha 2 Antibody - Immunohistochemistry of paraffin-embedded human kidney tissue at dilution of 1:100
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PRKAA2 / AMPK Alpha 2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
PRKAA2 / AMPK Alpha 2 Antibody - Immunofluorescence of monoclonal antibody to PRKAA2 on HeLa cell . [antibody concentration 10 ug/ml]
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PRKAA2 / AMPK Alpha 2 Mouse anti-Human Monoclonal (1G8) Antibody
Human
ELISA, IF, RNAi, WB
Unconjugated
100 µg/$423
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PRKAA2 / AMPK Alpha 2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$331
PRKAA2 / AMPK Alpha 2 Antibody - PRKAA2 (Thr172) antibody immunohistochemistry of formalin-fixed and paraffin-embedded human skeletal muscle followed by peroxidase-conjugated secondary antibody and DAB staining.This data demonstrates the use of the PRKAA2 (Thr172) antibody for immunohistochemistry.
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PRKAA2 / AMPK Alpha 2 Rabbit anti-Human Polyclonal (Thr172) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
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PRKAA2 / AMPK Alpha 2 Rabbit anti-Human Polyclonal (Thr172) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
200 µl/$734
Select
PRKAA2 / AMPK Alpha 2 Rabbit anti-Human Polyclonal (Thr172) (Biotin) Antibody
Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200 µl/$952
Select
PRKAA2 / AMPK Alpha 2 Rabbit anti-Human Polyclonal (Thr172) (FITC) Antibody
Human
ELISA, Flo, IHC, WB
FITC Conjugated
200 µl/$952
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PRKAA2 / AMPK Alpha 2 Rabbit anti-Human Polyclonal (Thr172) (APC) Antibody
Human
ELISA, Flo, IHC, WB
APC Conjugated
200 µl/$952
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PRKAA2 / AMPK Alpha 2 Rabbit anti-Human Polyclonal (Thr172) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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PRKAA2 / AMPK Alpha 2 Rabbit anti-Human Polyclonal (Thr172) (PE) Antibody
Human
ELISA, Flo, IHC, WB
PE Conjugated
200 µl/$952
PRKAA2 / AMPK Alpha 2 Antibody - Immunohistochemical analysis of paraffin-embedded rectum cancer tissues using PRKAA2 mouse mAb with DAB staining.
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PRKAA2 / AMPK Alpha 2 Mouse anti-Human Monoclonal (5B4G1) Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µl/$459
PRKAA2 / AMPK Alpha 2 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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PRKAA2 / AMPK Alpha 2 Rabbit anti-Human Polyclonal (aa343-552) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
PRKAA2 / AMPK Alpha 2 Antibody - Immunofluorescence analysis of A549 cells.
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PRKAA2 / AMPK Alpha 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$287; 100 µl/$431
PRKAA2 / AMPK Alpha 2 Antibody
Select
PRKAA2 / AMPK Alpha 2 Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, WB
Unconjugated
50 µl/$286; 100 µl/$321
Select
PRKAA2 / AMPK Alpha 2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
100 µg/$602
PRKAA2 / AMPK Alpha 2 Antibody - Immunofluorescence staining of PRKAA2 in MCF7 cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS, blocked with 10% serum, and incubated with rabbit anti-human PRKAA2 polyclonal antibody (dilution ratio 1:1000) at 4°C overnight. Then cells were stained with the Alexa Fluor 488-conjugated Goat Anti-rabbit IgG secondary antibody (green). Positive staining was localized to nucleus.
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PRKAA2 / AMPK Alpha 2 Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Rat, Human
ICC, IF, IHC-P
Unconjugated, Preservative Free
100 µl/$412
PRKAA2 / AMPK Alpha 2 Antibody - PRKAA2 antibody (1 ug/ml) staining of Human Liver lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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PRKAA2 / AMPK Alpha 2 Goat anti-Human Polyclonal (aa382-392) Antibody
Xenopus, Chicken, Bovine, Rat, Hamster, Pig, Horse, Bat, Rabbit, Mouse, Dog, Human, Monkey
ELISA, Peptide-ELISA, WB
Unconjugated
100 µg/$503
PRKAA2 / AMPK Alpha 2 Antibody - Fluorescent image of HeLa cell stained with PRKAA2 Antibody. HeLa cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.1%, 10 min), then incubated with PRKAA2 primary antibody (1:25, 1 h at 37°C). For secondary antibody, Alexa Fluor 488 conjugated donkey anti-mouse antibody (green) was used (1:400, 50 min at 37°C). Cytoplasmic actin was counterstained with Alexa Fluor 555 (red) conjugated Phalloidin (7units/ml, 1 h at 37°C). PRKAA2 immunoreactivity is localized to Cytoplasm significantly.
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PRKAA2 / AMPK Alpha 2 Mouse anti-Human Monoclonal Antibody
Human
IF, WB
Unconjugated
400 µl/$393
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).