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Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes.
|Gene Name:||perforin 1 (pore forming protein)|
|Synonyms:||PRF1, HPLH2, Perforin, p1, Perforin1, PFP, Cytolysin, FLH2, Perforin-1|
|Target Sequences:||NM_005041 NP_005032.2 P14222|
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