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PRAM1 is similar to FYN binding protein (FYB/SLAP-130), an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha).
Gene Name: | PML-RARA regulated adaptor molecule 1 |
Synonyms: | PRAM1, PML-RAR, PRAM, PRAM-1 |
Target Sequences: | NM_032152 NP_115528.4 Q96QH2 |
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