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May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins (By similarity). May also function as a chaperone, playing a role in transport to the cell membrane of BSG for instance (PubMed:15946952). May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation (PubMed:11435423).
Gene Name: | peptidylprolyl isomerase (cyclophilin)-like 2 |
Synonyms: | PPIL2, CYC4, CYP60, Cyclophilin-60, HCyP-60, Rotamase PPIL2, PPIase, Cyclophilin, 60kDa, Cyp-60 |
Target Sequences: | NM_014337 NP_055152.1 Q13356 |
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