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PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F1F0 ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.
Gene Name: | peptidylprolyl isomerase F |
Synonyms: | PPIF, Cyclophilin 3, CYP3, Cyp-D, HCyP3, Peptidylprolyl isomerase F, Rotamase F, PPIase F, Cyclophilin D, Cyclophilin F |
Target Sequences: | NM_005729 NP_005720.1 P30405 |
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