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PPIE / Cyclophilin E is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein contains a highly conserved cyclophilin (CYP) domain as well as an RNA-binding domain. It was shown to possess PPIase and protein folding activities, and it also exhibits RNA-binding activity. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 1, has been identified.
Gene Name: | peptidylprolyl isomerase E (cyclophilin E) |
Synonyms: | PPIE, Cyclophilin-33, CYP33, Cyclophilin E, CYP-33, PPIase E, Rotamase E |
Target Sequences: | NM_006112 NP_006103.1 Q9UNP9 |
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