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PPARGC1A / PGC-1 Alpha

peroxisome proliferator-activated receptor gamma, coactivator 1 alpha

Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK.

Gene Name:	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
Synonyms:	PPARGC1A, PGC-1-alpha, PGC-1v, PGC-1(alpha), PGC1, PPARgamma coactivator-1, PPARgamma coactivator-1alpha, Ligand effect modulator 6, Pgc-1, PPAR-gamma coactivator 1-alpha, L-PGC-1alpha, LEM6, Ligand effect modulator-6, PGC1A, PPARGC-1-alpha, PPARGC1
Target Sequences:	NM_013261 NP_037393.1 Q9UBK2

Publications (10)

Activation of a prometastatic gene expression program in hypoxic neuroblastoma cells. Poomthavorn P, Wong SH, Higgins S, Werther GA, Russo VC. Endocrine-related cancer. 2009 16:991-1004. [PubMed:19423615]

Hypoxia-induced angiogenesis is delayed in aging mouse brain. Benderro GF, Lamanna JC. Brain research. 2011 1389:50-60. [PubMed:21402058] [PMC:PMC3082052]

Multiparity leads to obesity and inflammation in mothers and obesity in male offspring. Rebholz SL, Jones T, Burke KT, Jaeschke A, Tso P, D'Alessio DA, Woollett LA. American journal of physiology. Endocrinology and metabolism. 2012 302:E449-57. [PubMed:22127227] [PMC:PMC3287352]

Low density lipoprotein (LDL) receptor-related protein 6 (LRP6) regulates body fat and glucose homeostasis by modulating nutrient sensing pathways and mitochondrial energy expenditure. Liu W, Singh R, Choi CS, Lee HY, Keramati AR, Samuel VT, Lifton RP, Shulman GI, Mani A. The Journal of biological chemistry. 2012 287:7213-23. [PubMed:22232553] [PMC:PMC3293520]

Dichotomous effects of VEGF-A on adipose tissue dysfunction. Sun K, Wernstedt Asterholm I, Kusminski CM, Bueno AC, Wang ZV, Pollard JW, Brekken RA, Scherer PE. Proceedings of the National Academy of Sciences of the United States of America. 2012 109:5874-9. (WB; Mouse) [PubMed:22451920] [PMC:PMC3326476]

Decreased VEGF expression and microvascular density, but increased HIF-1 and 2 accumulation and EPO expression in chronic moderate hyperoxia in the mouse brain. Benderro GF, Sun X, Kuang Y, Lamanna JC. Brain research. 2012 1471:46-55. (WB; Mouse) [PubMed:22820296] [PMC:PMC3454487]

Drosha mediates destabilization of Lin28 mRNA targets. Qiao C, Ma J, Xu J, Xie M, Ma W, Huang Y. Cell cycle (Georgetown, Tex.). 2012 11:3590-8. (WB; Human) [PubMed:22935707] [PMC:PMC3478310]

SIRT1 activating compounds reduce oxidative stress and prevent cell death in neuronal cells. Khan RS, Fonseca-Kelly Z, Callinan C, Zuo L, Sachdeva MM, Shindler KS. Frontiers in cellular neuroscience. 2012 6:63. (WB; Rat) [PubMed:23293585] [PMC:PMC3533205]

Age-associated molecular changes in the kidney in aged mice. Lim JH, Kim EN, Kim MY, Chung S, Shin SJ, Kim HW, Yang CW, Kim YS, Chang YS, Park CW, Choi BS. Oxidative medicine and cellular longevity. 2012 2012:171383. (WB; Mouse) [PubMed:23326623] [PMC:PMC3544311]

Characterization of Brown Adipose-Like Tissue in Trauma-Induced Heterotopic Ossification in Humans. Elizabeth A Salisbury, Austin R Dickerson, Thomas A Davis, Jonathan A Forsberg, Alan R Davis, Elizabeth A Olmsted-Davis. The American journal of pathology. 2017 September;187:2071-2079. [Full Text Article] [PubMed:28686851] [PMC:PMC5809335]

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