PPARG / PPAR Gamma

peroxisome proliferator-activated receptor gamma

Peroxisome proliferator-activated receptor gamma (PPAR gamma), a NR1 Thyroid Hormone-Like Receptor, is a transcription factor that regulates genes involved in lipid metabolism and adipocyte differentiation and has been shown to affect placental differentiation and cell proliferation and differentiation pathways in various diseases such as Type II diabetes and atherosclerosis. Recently, PPAR gamma has been suggested to affect inflammatory digestive diseases (Dubuquoy et al. 2002). PPAR gamma binds target DNA as a heterodimer (with retinoid X receptors) and has several coactivators, including steroid receptor coactivator-1 (SRC-1) and PPAR-binding protein (PBP). Two isoforms of PPAR gamma protein have been identified: PPAR gamma2 contains 30 additional amino acids at the N terminus compared to PPAR gamma1. PPAR gamma2 is expressed mainly in adipose tissue, whereas PPAR gamma1 is expressed widely. Mutations in PPAR gamma2 have been implicated in the development of obesity and Type II diabetes. PPAR gamma is the molecular target of thiazolidinediones (TZDs), drugs used widely for treatment of Type II diabetes, and is believed to mediate the apoptotic effects of this class of drugs in a variety of cell types, including B and T lymphocytes. Altered expression of PPAR gamma and cyclooxygenase-2 (COX-2) and the subsequent modulation in the tissue levels of PGE(2) and 15-d-PGJ(2) may influence the development of human breast cancer and its progression to metastasis.

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Products

Proteins (28)

Type

Over-Expression Lysate (10)

Recombinant (18)

Target

PPARG / PPAR Gamma (28)

Publications

No (28)

Tag

10His, N-terminus (1)

6His, N-terminus (1)

6His-SUMO, N-terminus (1)

GST (1)

GST, N-terminus (1)

His (7)

His, N-Terminal (1)

His-SUMO (1)

Myc-DDK (Flag) (14)

Species

Bovine (1)

Human (16)

Mouse (4)

Rabbit (1)

Rat (1)

Source

293T Cells (5)

E. coli (11)

HEK 293 Cells (9)

Wheat Germ Extract (2)

Yeast (1)

Purification

Purified (4)

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Human PPARG / PPAR Gamma Protein (Recombinant GST) (Full Length) - LS-G29830

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

77.99 kDa

Price:

10 µg/$479; 25 µg/$670

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Human PPARG / PPAR Gamma Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66550

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

57.4 kDa

Price:

20 µg/$1,107

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Rat PPARG / PPAR Gamma Protein (Recombinant His) (aa311-493) - LS-G13056

Source:

E. coli

Tag:

His

Molecular Weight:

22.3 kDa

Price:

10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284

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Human PPARG / PPAR Gamma Protein (Recombinant 6His, N-terminus) (aa1-477) - LS-G57240

Source:

Yeast

Tag:

6His, N-terminus

Price:

100 µg/$570; 20 µg/$395; 1 mg/$1,973

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Human PPARG / PPAR Gamma Protein (Recombinant His) - LS-G870

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human PPARG / PPAR Gamma Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66551

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.5 kDa

Price:

20 µg/$1,107

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Human PPARG / PPAR Gamma Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66552

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.5 kDa

Price:

20 µg/$1,107

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Human PPARG / PPAR Gamma Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66553

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.5 kDa

Price:

20 µg/$1,107

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PPARG / PPAR Gamma Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G107268

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.5 kDa

Price:

100 µg/$494

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PPARG / PPAR Gamma Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G107269

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.5 kDa

Price:

100 µg/$494

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PPARG / PPAR Gamma Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116229

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.5 kDa

Price:

100 µg/$494

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PPARG / PPAR Gamma Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101350

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

57.4 kDa

Price:

100 µg/$710

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PPARG / PPAR Gamma Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G127343

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.5 kDa

Price:

100 µg/$494

Select

Human PPARG / PPAR Gamma Protein (Recombinant His) (aa349-488) - LS-G13058

Source:

E. coli

Tag:

His

Molecular Weight:

17.4 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Bovine PPARG / PPAR Gamma Protein (Recombinant His) (aa311-500) - LS-G13048

Source:

E. coli

Tag:

His

Molecular Weight:

23.1 kDa

Price:

10 µg/$290; 50 µg/$497; 100 µg/$795; 200 µg/$992; 1 mg/$2,134; 500 µg/$1,658; 5 mg/$3,473; 2 mg/$2,324

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Mouse PPARG / PPAR Gamma Protein (Recombinant His) (aa149-273) - LS-G13049

Source:

E. coli

Tag:

His

Molecular Weight:

15.6 kDa

Price:

10 µg/$286; 50 µg/$472; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257

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Rabbit PPARG / PPAR Gamma Protein (Recombinant His) (aa280-475) - LS-G13050

Source:

E. coli

Tag:

His

Molecular Weight:

23.9 kDa

Price:

10 µg/$292; 50 µg/$512; 100 µg/$817; 200 µg/$1,018; 1 mg/$2,168; 500 µg/$1,690; 5 mg/$3,571; 2 mg/$2,359

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Human PPARG / PPAR Gamma Protein (Recombinant His) (aa157-274) - LS-G13051

Source:

E. coli

Tag:

His

Molecular Weight:

15.1 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Human PPARG / PPAR Gamma Protein (Recombinant His-SUMO) (aa1-477) - LS-G21071

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

70.6 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human PPARG / PPAR Gamma Protein (Recombinant GST, N-terminus) (aa366-475) - LS-G59681

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human PPARG / PPAR Gamma Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77982

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.5 kDa

Price:

20 µg/$150

Select

Human PPARG / PPAR Gamma Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77983

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

57.4 kDa

Price:

20 µg/$215

Select

Human PPARG / PPAR Gamma Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77984

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.5 kDa

Price:

20 µg/$150

Select

Human PPARG / PPAR Gamma Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77985

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.5 kDa

Price:

20 µg/$150

Select

Human PPARG / PPAR Gamma Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77986

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.5 kDa

Price:

20 µg/$150

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