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PPARG / PPAR Gamma

peroxisome proliferator-activated receptor gamma

Peroxisome proliferator-activated receptor gamma (PPAR gamma), a NR1 Thyroid Hormone-Like Receptor, is a transcription factor that regulates genes involved in lipid metabolism and adipocyte differentiation and has been shown to affect placental differentiation and cell proliferation and differentiation pathways in various diseases such as Type II diabetes and atherosclerosis. Recently, PPAR gamma has been suggested to affect inflammatory digestive diseases (Dubuquoy et al. 2002). PPAR gamma binds target DNA as a heterodimer (with retinoid X receptors) and has several coactivators, including steroid receptor coactivator-1 (SRC-1) and PPAR-binding protein (PBP). Two isoforms of PPAR gamma protein have been identified: PPAR gamma2 contains 30 additional amino acids at the N terminus compared to PPAR gamma1. PPAR gamma2 is expressed mainly in adipose tissue, whereas PPAR gamma1 is expressed widely. Mutations in PPAR gamma2 have been implicated in the development of obesity and Type II diabetes. PPAR gamma is the molecular target of thiazolidinediones (TZDs), drugs used widely for treatment of Type II diabetes, and is believed to mediate the apoptotic effects of this class of drugs in a variety of cell types, including B and T lymphocytes. Altered expression of PPAR gamma and cyclooxygenase-2 (COX-2) and the subsequent modulation in the tissue levels of PGE(2) and 15-d-PGJ(2) may influence the development of human breast cancer and its progression to metastasis.

Gene Name: peroxisome proliferator-activated receptor gamma
Family/Subfamily: NHR , NR1 Thyroid hormone-like
Synonyms: PPARG, NR1C3, PPAR gamma, PPAR gamma 2, PPARG1, PPARG2, PPARgamma, CIMT1, GLM1, PPAR-gamma
Target Sequences: NM_015869 NP_056953.2 P37231

Publications (6)

1
Effects of Cryopreservation on Canine Multipotent Stromal Cells from Subcutaneous and Infrapatellar Adipose Tissue. Duan W, Lopez MJ. Stem cell reviews. 2016 12:257-68. (ICC, Flo; Canine) [Full Text Article] [PubMed:26537238] [PMC:PMC4841859] Related Antibodies: LS-B651.
2
Inhibition of calpain delays early muscle atrophy after rotator cuff tendon release in sheep. Ruoss S, Kindt P, Oberholzer L, Rohner M, Jungck L, Abdel-Aziz S, Fitze D, Rosskopf AB, Klein K, von Rechenberg B, Gerber C, Wieser K, Flück M. Physiological reports. 2018 November;6:e13833. [Full Text Article] [PubMed:30393967] [PMC:PMC6215759] Related Antibodies: LS-C178333.
3
PPAR? Interaction with UBR5/ATMIN Promotes DNA Repair to Maintain Endothelial Homeostasis. Li CG, Mahon C, Sweeney NM, Verschueren E, Kantamani V, Li D, Hennigs JK, Marciano DP, Diebold I, Abu-Halawa O, Elliott M, Sa S, Guo F, Wang L, Cao A, Guignabert C, Sollier J, Nickel NP, Kaschwich M, Cimprich KA, Rabinovitch M. Cell reports. 2019 January;26:1333-1343. [Full Text Article] [PubMed:30699358] [PMC:PMC6436616] Related Antibodies: LS-C209422.
4
TAZ Is a Negative Regulator of PPAR? Activity in Adipocytes and TAZ Deletion Improves Insulin Sensitivity and Glucose Tolerance. Dalila El Ouarrat, Roi Isaac, Yun Sok Lee, Da Young Oh, Joshua Wollam, Denise Lackey, Matthew Riopel, Gautam Bandyopadhyay, Jong Bae Seo, Revathy Sampath-Kumar, Jerrold M Olefsky. Cell metabolism. 2020 January;31:162-173.e5. [PubMed:31708444] [PMC:PMC7784082] Related Antibodies: LS-B7391.
5
Genomic and lipidomic actions of nandrolone on detached rotator cuff muscle in sheep. Martin Flück, Severin Ruoss, Christoph B Möhl, Paola Valdivieso, Mario C Benn, Brigitte von Rechenberg, Endre Laczko, Junmin Hu, Karl Wieser, Dominik C Meyer, Christian Gerber. The Journal of steroid biochemistry and molecular biology. 2017 January;165:382-395. [Full Text Article] [PubMed:27523963] Related Antibodies: LS-C178333.
6
Improvement of a slimming cream's efficacy using a novel fabric as a transdermal drug delivery system: An                     in vivo                  and                     in vitro                  study. Kwang Ho Yoo, Tae-Rin Kwon, Chang Taek Oh, Kyeung Chan Ko, Yong Hwan No, Won Jong Oh, Beom Joon Kim. Experimental and therapeutic medicine. 2020 May;19:3282-3288. [Full Text Article] [PubMed:32266024] [PMC:PMC7132236] Related Antibodies: LS-B651.
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Products
Proteins (28)
Over-Expression Lysate (10)
Recombinant (18)
PPARG / PPAR Gamma (28)
No (28)
10His, N-terminus (1)
6His, N-terminus (1)
6His-SUMO, N-terminus (1)
GST (1)
GST, N-terminus (1)
His (7)
His, N-Terminal (1)
His-SUMO (1)
Myc-DDK (Flag) (14)
Bovine (1)
Human (16)
Mouse (4)
Rabbit (1)
Rat (1)
293T Cells (5)
E. coli (11)
HEK 293 Cells (9)
Wheat Germ Extract (2)
Yeast (1)
Purified (4)
PPARG / PPAR Gamma Protein - 12.5% SDS-PAGE of human PPARG stained with Coomassie Blue
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Wheat Germ Extract
GST
77.99 kDa
10 µg/$479; 25 µg/$670
PPARG / PPAR Gamma Protein - Purified recombinant protein PPARG was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
57.4 kDa
20 µg/$1,107
PPARG / PPAR Gamma Protein - Recombinant Peroxisome Proliferator Activated Receptor Gamma By SDS-PAGE
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E. coli
His
22.3 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
PPARG / PPAR Gamma Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Yeast
6His, N-terminus
100 µg/$570; 20 µg/$395; 1 mg/$1,973
PPARG / PPAR Gamma Protein
Select
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
PPARG / PPAR Gamma Protein - Purified recombinant protein PPARG was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
54.5 kDa
20 µg/$1,107
PPARG / PPAR Gamma Protein - Purified recombinant protein PPARG was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
54.5 kDa
20 µg/$1,107
PPARG / PPAR Gamma Protein - Purified recombinant protein PPARG was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
54.5 kDa
20 µg/$1,107
PPARG / PPAR Gamma Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
54.5 kDa
100 µg/$494
PPARG / PPAR Gamma Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
54.5 kDa
100 µg/$494
PPARG / PPAR Gamma Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
54.5 kDa
100 µg/$494
PPARG / PPAR Gamma Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
57.4 kDa
100 µg/$710
PPARG / PPAR Gamma Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
54.5 kDa
100 µg/$494
PPARG / PPAR Gamma Protein - Recombinant Peroxisome Proliferator Activated Receptor Gamma By SDS-PAGE
Select
E. coli
His
17.4 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
PPARG / PPAR Gamma Protein - Recombinant Peroxisome Proliferator Activated Receptor Gamma By SDS-PAGE
Select
E. coli
His
23.1 kDa
10 µg/$290; 50 µg/$497; 100 µg/$795; 200 µg/$992; 1 mg/$2,134; 500 µg/$1,658; 5 mg/$3,473; 2 mg/$2,324
PPARG / PPAR Gamma Protein - Recombinant Peroxisome Proliferator Activated Receptor Gamma By SDS-PAGE
Select
E. coli
His
15.6 kDa
10 µg/$286; 50 µg/$472; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257
PPARG / PPAR Gamma Protein - Recombinant Peroxisome Proliferator Activated Receptor Gamma By SDS-PAGE
Select
E. coli
His
23.9 kDa
10 µg/$292; 50 µg/$512; 100 µg/$817; 200 µg/$1,018; 1 mg/$2,168; 500 µg/$1,690; 5 mg/$3,571; 2 mg/$2,359
PPARG / PPAR Gamma Protein - Recombinant Peroxisome Proliferator Activated Receptor Gamma By SDS-PAGE
Select
E. coli
His
15.1 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
Select
E. coli
His-SUMO
70.6 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
PPARG / PPAR Gamma Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
PPARG / PPAR Gamma Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
54.5 kDa
20 µg/$150
PPARG / PPAR Gamma Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
57.4 kDa
20 µg/$215
PPARG / PPAR Gamma Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
54.5 kDa
20 µg/$150
Select
293T Cells
Myc-DDK (Flag)
54.5 kDa
20 µg/$150
Select
293T Cells
Myc-DDK (Flag)
54.5 kDa
20 µg/$150
Viewing 1-25 of 28 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).