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PPARD / PPAR Delta

peroxisome proliferator-activated receptor delta

PPARD / PPAR Delta is a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants.

Gene Name: peroxisome proliferator-activated receptor delta
Family/Subfamily: NHR , NR1 Thyroid hormone-like
Synonyms: PPARD, FAAR, NUCI, PPAR-beta, PPAR-delta, NR1C2, NUC1, NUCII, Nuclear hormone receptor 1, PPARB, PPAR Delta
Target Sequences: NM_006238 NP_006229.1 Q03181

Publications (2)

1
Transcript profiling identifies dynamic gene expression patterns and an important role for Nrf2/Keap1 pathway in the developing mouse esophagus. Chen H, Li J, Li H, Hu Y, Tevebaugh W, Yamamoto M, Que J, Chen X. PloS one. 2012 7:e36504. (IHC-P; Mouse) [Full Text Article] [PubMed:22567161] [PMC:PMC3342176] Related Antibodies: LS-B45.
2
The PPARd Agonist GW501516 Improves Lipolytic/Lipogenic Balance through CPT1 and PEPCK during the Development of Pre-Implantation Bovine Embryos. Muhammad Idrees, Lianguang Xu, Marwa El Sheikh, Tabinda Sidrat, Seok-Hwan Song, Myeong-Don Joo, Kyeong-Lim Lee, Il-Keun Kong. International journal of molecular sciences. 2019 Dec;20:6066. [Full Text Article] [PubMed:31810173] [PMC:PMC6928732] Related Antibodies: LS-C437498.

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Products
ELISA Kits (14)
Custom (1)
Development Kit (1)
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PPARD / PPAR Delta (14)
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Mouse (3)
Rat (1)
Chicken (1)
Dog (1)
Guinea pig (1)
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12 x 8-Well Microstrips (1)
96-Well Microplate (1)
96-Well Strip Plate (11)
Antibody Pair and Standard (1)
No (14)
Cell Culture Supernatants (2)
Cell Lysates (2)
Plasma (5)
Serum (5)
Tissue Homogenates (4)
PPARD / PPAR Delta ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
PPARD / PPAR Delta ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
1 Plate/$834
PPARD / PPAR Delta ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
PPARD / PPAR Delta ELISA Kit
Select
Sandwich
96-Well Strip Plate
Chicken
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
PPARD / PPAR Delta ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
PPARD / PPAR Delta ELISA Kit
Select
Sandwich
96-Well Strip Plate
Guinea pig
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
PPARD / PPAR Delta ELISA Kit
Select
Sandwich
96-Well Strip Plate
Porcine
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
PPARD / PPAR Delta ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
PPARD / PPAR Delta ELISA Kit
Select
Custom
96-Well Strip Plate
Dog
Colorimetric - 450nm (TMB)
1 Plate/$929
PPARD / PPAR Delta ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Rat
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
PPARD / PPAR Delta ELISA Kit
Select
Sandwich
96-Well Microplate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
PPARD / PPAR Delta ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
PPARD / PPAR Delta ELISA Kit
Select
Development Kit
Antibody Pair and Standard
Mouse
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
500 Wells/$1,302; 1000 Wells/$1,947
PPARD / PPAR Delta ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$854
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).