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PPAP2C is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.
Gene Name: | phosphatidic acid phosphatase type 2C |
Synonyms: | PPAP2C, PAP2c, PAP2-g, LPP2, PAP-2c, PAP2-gamma |
Target Sequences: | NM_003712 NP_003703.1 O43688 |
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