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POU2F3 / PLA-1
POU class 2 homeobox 3
POU2F3 / PLA-1 is a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
| Gene Name: | POU class 2 homeobox 3 |
| Synonyms: | POU2F3, Epoc-1, Octamer-binding protein 11, POU class 2 homeobox 3, Transcription factor PLA-1, Transcription factor Skn-1, PLA-1, PLA1, OCT-11, OCT11, OTF-11, OTF11, Skn-1a |
| Target Sequences: | NM_014352 NP_055167.2 Q9UKI9 |
Publications (1)
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