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DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity.
Gene Name: | polymerase (DNA directed) kappa |
Synonyms: | POLK, DINP, DNA polymerase kappa, DINB1, DINB protein |
Target Sequences: | NM_016218 NP_057302.1 Q9UBT6 |
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