POLI

polymerase (DNA directed) iota

Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.

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Products

Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

POLI (5)

Publications

No (5)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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POLI Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114793

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

80.32 kDa

Price:

100 µg/$710

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Human POLI Protein (Recombinant GST) (Full Length) - LS-G32559

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

106.7 kDa

Price:

10 µg/$479; 25 µg/$670

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Human POLI Protein (Recombinant GST, N-terminus) (aa616-715) - LS-G61782

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human POLI Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68785

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

82.8 kDa

Price:

20 µg/$1,107

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Human POLI Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G83085

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

80.32 kDa

Price:

20 µg/$215

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