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POLG2

polymerase (DNA directed), gamma 2, accessory subunit

POLG2 is the processivity subunit of the mitochondrial DNA polymerase gamma. The encoded protein forms a heterotrimer containing one catalytic subunit and two processivity subunits. This protein enhances DNA binding and promotes processive DNA synthesis. Mutations in this gene result in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions.

Gene Name: polymerase (DNA directed), gamma 2, accessory subunit
Synonyms: POLG2, MTPOLB, PEOA4, POLG-BETA, POLGB, HP55, p55
Target Sequences: NM_007215 NP_009146.2 Q9UHN1

Publications (2)

1
RNase H1 Regulates Mitochondrial Transcription and Translation via the Degradation of 7S RNA. Aurelio Reyes, Joanna Rusecka, Katarzyna Tonska, Massimo Zeviani. Frontiers in genetics. 2020 Jan;10:1393. [Full Text Article] [PubMed:32082360] [PMC:PMC7006045] Related Antibodies: LS-C334882.
2
DNA polymerase gamma mutations that impair holoenzyme stability cause catalytic subunit depletion10<sup> Venetian Institute of Molecular Medicine, via Orus 2-35128 Padova, Italy. Pedro Silva-Pinheiro, Carlos Pardo-Hernández, Aurelio Reyes, Lisa Tilokani, Anup Mishra, Raffaele Cerutti, Shuaifeng Li, Dieu-Hien Rozsivalova, Sebastian Valenzuela, Sukru A Dogan, Bradley Peter, Patricio Fernández-Silva, Aleksandra Trifunovic, Julien Prudent, Michal Minczuk, Laurence Bindoff , Bertil Macao, Massimo Zeviani , Maria Falkenberg, Carlo Viscomi. Nucleic acids research. 2021 May;49:5230-5248. [Full Text Article] [PubMed:33956154] [PMC:PMC8136776] Related Antibodies: LS-C334882.

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Products
Antibodies (18)
Primary (18)
POLG2 (18)
Human (18)
Mouse (6)
Rat (5)
Chimpanzee (3)
Gibbon (3)
Monkey (3)
IHC (7)
IHC-P (3)
WB (10)
ELISA (7)
IF (2)
Peptide-ELISA (1)
rabbit (18)
IgG (12)
polyclonal pc (18)
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
Preservative Free (1)
Unconjugated (12)
aa1-485 (4)
aa45-94 (4)
260-340 aa, Internal (1)
Internal (1)
aa291-340 (1)
No (17)
Yes (1)
POLG2 Antibody - Immunohistochemistry of paraffin-embedded rat heart tissue.
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POLG2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
POLG2 Antibody - Immunohistochemical analysis of DNA Polymerase gamma 2 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP-conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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POLG2 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$299
POLG2 Antibody - Immunohistochemistry analysis of paraffin-embedded human cervix carcinoma tissue, using POLG2 Antibody. The picture on the right is blocked with the synthesized peptide.
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POLG2 Rabbit anti-Human Polyclonal (aa291-340) Antibody
Human
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
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POLG2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$331
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POLG2 Rabbit anti-Human Polyclonal (260-340 aa, Internal) Antibody
Human
ELISA, IHC
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
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POLG2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
POLG2 Antibody - Peptide - + Immunohistochemistry analysis of paraffin-embedded human cervix carcinoma tissue using POLG2 antibody.
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POLG2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC
Unconjugated
100 µg/$357
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POLG2 Rabbit anti-Human Polyclonal (aa1-485) Antibody
Human
ELISA
Unconjugated
50 µg/$294; 100 µg/$360
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POLG2 Rabbit anti-Human Polyclonal (aa1-485) (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
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POLG2 Rabbit anti-Human Polyclonal (aa1-485) (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
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POLG2 Rabbit anti-Human Polyclonal (aa1-485) (FITC) Antibody
Human
ELISA
FITC Conjugated
50 µg/$294; 100 µg/$360
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POLG2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
POLG2 Antibody - POLG2 antibody Western blot of Fetal Kidney lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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POLG2 Rabbit anti-Human Polyclonal (aa45-94) Antibody
Human
WB
Unconjugated
100 µl/$424
POLG2 Antibody - POLG2 antibody Western blot of Fetal Kidney lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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POLG2 Rabbit anti-Human Polyclonal (aa45-94) (HRP) Antibody
Human, Monkey, Chimpanzee, Gibbon
WB
HRP Conjugated
100 µl/$469
POLG2 Antibody - POLG2 antibody Western blot of Fetal Kidney lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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POLG2 Rabbit anti-Human Polyclonal (aa45-94) (Biotin) Antibody
Human, Monkey, Chimpanzee, Gibbon
WB
Biotin Conjugated
100 µl/$469
POLG2 Antibody - POLG2 antibody Western blot of Fetal Kidney lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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POLG2 Rabbit anti-Human Polyclonal (aa45-94) (FITC) Antibody
Human, Monkey, Chimpanzee, Gibbon
WB
FITC Conjugated
100 µl/$469
POLG2 Antibody - Western blot of POLG2 antibody at 1:500 dilution. Lane 1: A549 whole cell lysate. Lane 2: HeLa whole cell lysate. Lane 3: H9C2 whole cell lysate. Lane 4: SP20 whole cell lysate.
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POLG2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
50 µl/$321; 100 µl/$403
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POLG2 Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
IHC-P
Unconjugated, Preservative Free
100 µl/$412
Viewing 1-18 of 18 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).