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POLD4 is the smallest subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein enhances the activity of DNA polymerase delta and plays a role in fork repair and stabilization through interactions with the DNA helicase Bloom syndrome protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Gene Name: | polymerase (DNA-directed), delta 4, accessory subunit |
Synonyms: | POLD4, p12, POLDS, DNA polymerase delta subunit 4 |
Target Sequences: | NM_021173 |
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