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PNPLA2 / ATGL
patatin-like phospholipase domain containing 2
Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets. Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes. May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion.
| Gene Name: | patatin-like phospholipase domain containing 2 |
| Synonyms: | PNPLA2, Adipose triglyceride lipase, ATGL, IPLA2zeta, PEDF-R, IPLA2-zeta, Triglyceride hydrolase, TTS-2.2, TTS2, Transport-secretion protein 2, TTS2.2, Desnutrin, FP17548 |
| Target Sequences: | X56789 NP_065109.1 Q96AD5 |
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