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PNKP
polynucleotide kinase 3'-phosphatase
Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone.
| Gene Name: | polynucleotide kinase 3'-phosphatase |
| Synonyms: | PNKP, EIEE10, DNA 5-kinase/3-phosphatase, PNK, MCSZ |
| Target Sequences: | NM_007254 NP_009185.2 Q96T60 |
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