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PMEL / SILV / gp100

premelanosome protein

PMEL / SILV / gp100 is a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants.

Gene Name: premelanosome protein
Synonyms: PMEL, gp100, Melanocyte protein PMEL, Me20m/me20s, p100, PMEL17, Premelanosome protein, SIL, Silver homolog (mouse), Silver, mouse, homolog of, Silver locus protein homolog, ME20-M, Me20-m/me20-s, ME20M, Melanocyte protein mel 17, Melanocyte protein Pmel 17, Silver (mouse homolog) like, D12S53E, ME20, Melanosomal matrix protein17, SILV
Target Sequences: NM_006928 NP_008859.1 P40967

Publications (2)

1
Low-dose radiation treatment enhances systemic antitumor immune responses by overcoming the inhibitory stroma. Hampartsoum B Barsoumian, Rishab Ramapriyan, Ahmed I Younes, Mauricio S Caetano, Hari Menon, Nathan I Comeaux, Taylor R Cushman, Jonathan E Schoenhals, Alexandra P Cadena, Timothy P Reilly, Dawei Chen, Fatemeh Masrorpour, Ailin Li, David S Hong, Adi Diab, Quynh-Nhu Nguyen, Isabella Glitza, Renata Ferrarotto, Stephen G Chun, Maria Angelica Cortez, James Welsh. Journal for immunotherapy of cancer. 2020 October;8: [Full Text Article] [PubMed:33106386] [PMC:PMC7592253]
2
Landscape mapping of shared antigenic epitopes and their cognate TCRs of tumor-infiltrating T lymphocytes in melanoma. Kenji Murata , Munehide Nakatsugawa , Muhammed A Rahman, Linh T Nguyen, Douglas G Millar, David T Mulder, Kenji Sugata, Hiroshi Saijo, Yukiko Matsunaga, Yuki Kagoya, Tingxi Guo, Mark Anczurowski, Chung-Hsi Wang, Brian D Burt, Dalam Ly, Kayoko Saso, Alexandra Easson, David P Goldstein, Michael Reedijk, Danny Ghazarian, Trevor J Pugh, Marcus O Butler, Tak W Mak, Pamela S Ohashi, Naoto Hirano. eLife. 2020 Apr;9:e53244. [Full Text Article] [PubMed:32314731] [PMC:PMC7234812] Related Antibodies: LS-C114528.

☰ Filters
Products
Antibodies (69)
Primary (69)
PMEL / SILV / gp100 (69)
Human (66)
Mouse (6)
Rat (9)
Chimpanzee (3)
Dog (5)
Gibbon (3)
Horse (4)
Monkey (7)
Pig (5)
IHC (33)
IHC-Fr (2)
IHC-P (32)
WB (33)
Flo (16)
ELISA (18)
IF (24)
Peptide-ELISA (2)
rabbit (22)
mouse (46)
goat (1)
Product Group
IHCPlus (1)
IgG (22)
IgG1 (12)
IgG1,k (16)
IgG2b (10)
IgG2b,k (4)
monoclonal mc (46)
polyclonal pc (21)
recombinant monoclonal rmc (2)
ABT-PMEL (1)
HMB45 + PMEL/783 (3)
MSSG95 (3)
MSSG95-2 (2)
NKI-beteb (2)
OTI10E5 (2)
OTI1E5 (2)
OTI3G5 (2)
OTI4D12 (2)
OTI4H4 (2)
OTI6D5 (2)
OTI7B2 (2)
OTI7E3 (2)
OTI8A4 (2)
OTI9G3 (2)
PMEL/1825R (2)
PMEL/2037 (2)
PMEL/2038 (2)
PMEL/2039 (2)
PMEL/783 (3)
SPM142 (2)
SPM286 (2)
APC Conjugated (1)
Azide-free (13)
Biotin Conjugated (3)
BSA-free (10)
Carrier-free (11)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (1)
Ready-to-Use (3)
Unconjugated (58)
aa25-467 (9)
aa412-440 (7)
aa231-280 (4)
C-Terminus (2)
aa647-660 (1)
No (68)
Yes (1)
PMEL / SILV / gp100 Antibody - Anti-PMEL / SILV antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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PMEL / SILV / gp100 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
100 µl/$440
PMEL / SILV / gp100 Antibody - HepG2 cell lysate. Antibody concentration: 1.25 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PMEL / SILV / gp100 Rabbit anti-Human Polyclonal (aa231-280) Antibody
Human
IHC, WB
Unconjugated
100 µl/$397
PMEL / SILV / gp100 Antibody - Anti-PMEL / SILV / gp100 antibody IHC staining of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PMEL / SILV / gp100 Rabbit anti-Human Polyclonal (aa231-280) (Biotin) Antibody
Mouse, Rat, Chimpanzee, Gibbon, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$442
PMEL / SILV / gp100 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SILV (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SILV.
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PMEL / SILV / gp100 Mouse anti-Human Monoclonal (aa25-467) (OTI1E5) Antibody
Human
WB
Unconjugated
100 µl/$434
PMEL / SILV / gp100 Antibody - HEK293T cells transfected with either pCMV6-ENTRY SILV (Red) or empty vector control plasmid (Blue) were immunostained with anti-SILV mouse monoclonal(Dilution 1:1,000), and then analyzed by flow cytometry.
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PMEL / SILV / gp100 Mouse anti-Human Monoclonal (OTI7E3) Antibody
Human
Flo, IHC
Unconjugated
100 µl/$434
PMEL / SILV / gp100 Antibody - IHC of paraffin-embedded pancreas tissue using anti-SILV mouse monoclonal antibody. (Dilution 1:50).
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PMEL / SILV / gp100 Mouse anti-Human Monoclonal (OTI10E5) Antibody
Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
PMEL / SILV / gp100 Antibody - IHC of paraffin-embedded pancreas tissue using anti-SILV mouse monoclonal antibody. (Dilution 1:50).
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PMEL / SILV / gp100 Mouse anti-Human Monoclonal (Carrier-free) (OTI10E5) Antibody
Dog, Rat, Human, Monkey
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
PMEL / SILV / gp100 Antibody - Anti-SILV mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SILV.
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PMEL / SILV / gp100 Mouse anti-Human Monoclonal (OTI8A4) Antibody
Dog, Rat, Human, Monkey
IF, WB
Unconjugated
100 µl/$434
Select
PMEL / SILV / gp100 Mouse anti-Human Monoclonal Antibody
Human
IHC, IHC-Fr
Unconjugated
100 µl/$394
Select
PMEL / SILV / gp100 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, WB
Unconjugated
0.1 mg/$379
Select
PMEL / SILV / gp100 Rabbit anti-Human Polyclonal (aa412-440) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
Select
PMEL / SILV / gp100 Rabbit anti-Human Polyclonal (aa412-440) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
Select
PMEL / SILV / gp100 Rabbit anti-Human Polyclonal (aa412-440) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
PMEL / SILV / gp100 Antibody - 1:100 staining human lymph node tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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PMEL / SILV / gp100 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
PMEL / SILV / gp100 Antibody - Formalin-fixed, paraffin-embedded human melanoma stained with gp100 antibody (HMB45 + PMEL/783).  This image was taken for the unmodified form of this product. Other forms have not been tested.
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PMEL / SILV / gp100 Mouse anti-Pig Monoclonal (Azide-free, BSA-free) (HMB45 + PMEL/783) Antibody
Pig, Human
Flo, IF, IHC, IHC-P
Unconjugated, Azide-free, BSA-free
100 µg/$574
PMEL / SILV / gp100 Antibody - Formalin-fixed, paraffin-embedded human melanoma stained with gp100 antibody (SPM142).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
PMEL / SILV / gp100 Mouse anti-Pig Monoclonal (SPM142) Antibody
Pig, Human
Flo, IF, IHC, IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
Select
PMEL / SILV / gp100 Rabbit anti-Human Polyclonal (aa25-467) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
PMEL / SILV / gp100 Antibody - Antibody (1 ug/ml) staining of Human Skin lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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PMEL / SILV / gp100 Goat anti-Human Polyclonal (aa647-660) Antibody
Human
Peptide-ELISA, WB
Unconjugated
100 µg/$503
PMEL / SILV / gp100 Antibody - Melanoma gp100 antibody NKI-beteb immunohistochemistry melanoma.  This image was taken for the unmodified form of this product. Other forms have not been tested.
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PMEL / SILV / gp100 Mouse anti-Human Monoclonal (NKI-beteb) Antibody
Horse, Human
ELISA, Flo, IF, IHC, IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
PMEL / SILV / gp100 Antibody - Melanoma gp100 antibody NKI-beteb immunohistochemistry melanoma.  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
PMEL / SILV / gp100 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (NKI-beteb) Antibody
Horse, Human
ELISA, Flo, IF, IHC, IHC-P
Unconjugated, Azide-free, BSA-free
100 µg/$574
PMEL / SILV / gp100 Antibody - Formalin-fixed, paraffin-embedded human melanoma stained with anti-gp100 antibody (SPM286).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
PMEL / SILV / gp100 Mouse anti-Human Monoclonal (SPM286) Antibody
Horse, Human
Flo, IF, IHC, IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
PMEL / SILV / gp100 Antibody - Formalin-fixed, paraffin-embedded human melanoma stained with anti-gp100 antibody (SPM286).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
PMEL / SILV / gp100 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (SPM286) Antibody
Horse, Human
Flo, IF, IHC, IHC-P
Unconjugated, Azide-free, BSA-free
100 µg/$574
PMEL / SILV / gp100 Antibody - Formalin-fixed, paraffin-embedded human melanoma stained with PMEL17 antibody (PMEL/783).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
PMEL / SILV / gp100 Mouse anti-Human Monoclonal (PMEL/783) Antibody
Human
Flo, IF, IHC, IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
PMEL / SILV / gp100 Antibody - Formalin-fixed, paraffin-embedded human melanoma stained with PMEL17 antibody (PMEL/783).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
PMEL / SILV / gp100 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (PMEL/783) Antibody
Human
Flo, IF, IHC, IHC-P
Unconjugated, Azide-free, BSA-free
100 µg/$574
PMEL / SILV / gp100 Antibody - Formalin-fixed, paraffin-embedded human melanoma stained with PMEL17 antibody (PMEL/783).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
PMEL / SILV / gp100 Mouse anti-Human Monoclonal (Ready-to-Use) (PMEL/783) Antibody
Human
Flo, IF, IHC, IHC-P
Unconjugated, Ready-to-Use
7 ml/$574
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).