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Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
Gene Name: | plexin A1 |
Synonyms: | PLXNA1, NOVP, Plexin A1, Plexin-A1, Plexin 1, PLXN1, Semaphorin receptor NOV |
Target Sequences: | NM_032242 |
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