PLK4 / SAK

polo-like kinase 4

Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

PLK4 / SAK (3)

Publications

No (3)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (2)

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293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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PLK4 / SAK Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101186

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

108.8 kDa

Price:

100 µg/$494

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Human PLK4 / SAK Protein (Recombinant GST, N-terminus) (aa1-110) - LS-G61622

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human PLK4 / SAK Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G83163

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

108.8 kDa

Price:

20 µg/$150

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