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May be a transforming oncogene with exchange activity for CDC42 By similarity. May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein).
Gene Name: | pleckstrin homology domain containing, family G (with RhoGef domain) member 2 |
Synonyms: | PLEKHG2, CLG, ARHGEF42 |
Target Sequences: | NP_073746.2 Q9H7P9 |
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