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PLDN / Pallidin
biogenesis of lysosomal organelles complex-1, subunit 6, pallidin
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process.
| Gene Name: | biogenesis of lysosomal organelles complex-1, subunit 6, pallidin |
| Synonyms: | BLOC1S6, HPS9, Pallid protein homolog, Pallidin, Pallidin homolog (mouse), PLDN, Syntaxin 13 binding protein 1, Pa, PALLID |
| Target Sequences: | NM_012388 NP_036520.1 Q9UL45 |
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