PLD6 / Phospholipase D6

phospholipase D family, member 6

Regulates mitochondrial shape through facilitating mitochondrial fusion. During spermatogenesis, plays a critical role in PIWI-interacting RNA (piRNA) biogenesis By similarity. piRNAs provide essential protection against the activity of mobile genetic elements. piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. Has been shown to be a backbone-non-specific, single strand-specific nuclease, cleaving either RNA or DNA substrates with similar affinity By similarity. Produces 5' phosphate and 3' hydroxyl termini, suggesting it could directly participate in the processing of primary piRNA transcripts By similarity. Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface. Although it cannot be excluded that it can act as a phospholipase in some circumstances, it should be noted that cardiolipin hydrolase activity is either undetectable in vitro, or very low (PubMed:21397848). In addition, cardiolipin is almost exclusively found on the inner mitochondrial membrane, while PLD6 localizes to the outer mitochondrial membrane, facing the cytosol.

☰ Filters

Products

Proteins (2)

Type

Recombinant (2)

Target

PLD6 / Phospholipase D6 (2)

Publications

No (2)

Tag

6His-SUMO, N-terminus (1)

GST (1)

Species

Human (2)

Source

E. coli (1)

Wheat Germ Extract (1)

Purification

Purified (2)

Select

Human PLD6 / Phospholipase D6 Protein (Recombinant GST) (Full Length) - LS-G36965

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

54.6 kDa

Price:

2 µg/$439

Select

Human PLD6 / Phospholipase D6 Protein (Recombinant 6His-SUMO, N-terminus) (aa1-252) - LS-G64251

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

Viewing 1-2 of 2 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: Proteins

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.