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PLD2 / Phospholipase D2 catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1. This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization, cell cycle control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding different isoforms have been found for this gene.
Gene Name: | phospholipase D2 |
Family/Subfamily: | Phospholipase , not assigned-Phospholipase |
Synonyms: | PLD2, Choline phosphatase 2, Phospholipase D2, HPLD2, PLD 2, PLD1C |
Target Sequences: | NM_002663 NP_002654.3 O14939 |
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