Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
PLCG2 / PLC Gamma 2 is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3.
|Gene Name:||phospholipase C, gamma 2 (phosphatidylinositol-specific)|
|Family/Subfamily:||Phospholipase , not assigned-Phospholipase|
|Synonyms:||PLCG2, FCAS3, Phospholipase C-gamma-2, PLCG 2, PLC-IV, APLAID, Phospholipase C-IV, PLC-gamma-2|
|Target Sequences:||NM_002661 NP_002652.2 P16885|
If you do not find the reagent or information you require, please contact email@example.com to inquire about additional products in development.