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PLCB1 / Phospholipase C Beta 1 catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene.
Gene Name: | phospholipase C, beta 1 (phosphoinositide-specific) |
Family/Subfamily: | Phospholipase , not assigned-Phospholipase |
Synonyms: | PLCB1, EIEE12, KIAA0581, Phospholipase C Beta 1, Phospholipase C-I, Phosphoinositidase C, PI-PLC, Inositoltrisphosphohydrolase, PLC-I, PLCB1A, PLC-beta-1, Phospholipase C-beta-1, PLC154, PLC-154, PLCB1B |
Target Sequences: | NM_015192 NP_056007.1 Q9NQ66 |
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