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PLAUR / CD87 / uPAR is the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined.
Gene Name: | plasminogen activator, urokinase receptor |
Family/Subfamily: | Protease Receptor , not assigned-Other |
Synonyms: | PLAUR, CD87 antigen, UPA receptor, URKR, U-PAR, UPAR, CD87, MO3 |
Target Sequences: | NM_002659 NP_002650.1 Q03405 |
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