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PLAT / TPA

plasminogen activator, tissue

PLAT / TPA is tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.

Gene Name: plasminogen activator, tissue
Family/Subfamily: Protease , Serine S1
Synonyms: PLAT, Plasminogen activator, Plasminogen activator, tissue, Tissue plasminogen activator, T-PA, T-plasminogen activator, TPA
Target Sequences: NM_000930 NP_000921.1 P00750

☰ Filters
Products
Proteins (20)
Over-Expression Lysate (4)
Recombinant (16)
PLAT / TPA (20)
No (20)
6His, C-terminus (2)
Fc (2)
Fc, N-terminus (1)
GST (1)
GST, N-terminus + His, C-terminus (1)
His (2)
His-GST (2)
His-SUMO (2)
His-T7 (1)
Myc-DDK (Flag) (5)
Human (14)
Mouse (2)
Pig (1)
Rat (1)
293T Cells (2)
E. coli (8)
HEK 293 Cells (4)
Human Cells (4)
Mammalian Cells (1)
Wheat Germ Extract (1)
Purified (2)
Low endotoxin level (6)
PLAT / TPA Protein
Select
E. coli
His-SUMO
74.2 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
PLAT / TPA Protein - Recombinant Plasminogen Activator, Tissue By SDS-PAGE
Select
E. coli
His-GST
89.2 kDa
10 µg/$289; 50 µg/$492; 100 µg/$785; 200 µg/$982; 1 mg/$2,119; 500 µg/$1,646; 5 mg/$3,431; 2 mg/$2,309
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
61.65kD
10 µg/$321; 50 µg/$534; 500 µg/$1,680; 1 mg/$2,353
PLAT / TPA Protein - Recombinant Plasminogen Activator, Tissue By SDS-PAGE
Select
E. coli
His
21.0 kDa
10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252
PLAT / TPA Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
54.9 kDa
100 µg/$494
PLAT / TPA Protein
Select
E. coli
GST, N-terminus + His, C-terminus
82.9 kDa
50 µg/$419
PLAT / TPA Protein
Select
E. coli
His-SUMO
43 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
PLAT / TPA Protein - 12.5% SDS-PAGE of human PLAT stained with Coomassie Blue
Select
Wheat Germ Extract
GST
89.3 kDa
2 µg/$439
PLAT / TPA Protein - Purified recombinant protein PLAT was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
54.9 kDa
20 µg/$1,107
Select
Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
56.4 kDa
20 µg/$649
PLAT / TPA Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
62.89 kDa
20 µg/$150
Select
293T Cells
Myc-DDK (Flag)
54.9 kDa
20 µg/$150
PLAT / TPA Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
62.89 kDa
100 µg/$494
Select
Human Cells
None
Less than 1.0 EU/µg protein (determined by LAL method).
28 kDa
20 µg/$603
Select
Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
54.8 kDa
20 µg/$603
PLAT / TPA Protein - Recombinant Plasminogen Activator, Tissue By SDS-PAGE
Select
E. coli
His
12.0 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
PLAT / TPA Protein - Recombinant Plasminogen Activator, Tissue By SDS-PAGE
Select
E. coli
His-GST
59.8 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
PLAT / TPA Protein - Recombinant Plasminogen Activator, Tissue By SDS-PAGE
Select
E. coli
His-T7
23.8 kDa
10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
Select
HEK 293 Cells
Fc, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
57.5 kDa
20 µg/$603
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
61.7 kDa
10 µg/$317; 50 µg/$524
Viewing 1-20 of 20 product results


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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).