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Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumor in childhood. Cooperates with CBFB-MYH11, a fusion gene important for myeloid leukemia.
Gene Name: | pleiomorphic adenoma gene 1 |
Synonyms: | PLAG1, COL1A2/PLAG1 fusion, Pleiomorphic adenoma gene 1, PSA, SGPA, ZNF912, Zinc finger protein PLAG1 |
Target Sequences: | NM_002655 NP_002646.2 Q6DJT9 |
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