PLA2R / PLA2R1

phospholipase A2 receptor 1, 180kDa

Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B.

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Products

Proteins (9)

Type

Over-Expression Lysate (2)

Recombinant (7)

Target

PLA2R / PLA2R1 (9)

Publications

No (9)

Tag

6His, N-terminus (1)

DDK,C-terminus (1)

His (2)

His-GST-S (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (8)

Mouse (1)

Source

293T Cells (1)

CHO Cells (1)

E. coli (3)

HEK 293 Cells (2)

Mammalian Cells (1)

Yeast (1)

Purification

Purified (1)

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Human PLA2R / PLA2R1 Protein (Recombinant DDK,C-terminus) (aa38-651) - LS-G145315

Source:

CHO Cells

Tag:

DDK,C-terminus

Molecular Weight:

77.5 kDa

Price:

50 µg/$677

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Human PLA2R / PLA2R1 Protein (Recombinant His-T7) (aa385-643) - LS-G15374

Source:

E. coli

Tag:

His-T7

Molecular Weight:

33.6 kDa

Price:

10 µg/$292; 50 µg/$512; 100 µg/$817; 200 µg/$1,018; 1 mg/$2,168; 500 µg/$1,690; 5 mg/$3,571; 2 mg/$2,359

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Human PLA2R / PLA2R1 Protein (Recombinant His) (aa395-530) - LS-G23394

Source:

Yeast

Tag:

His

Molecular Weight:

17.45 kD

Price:

100 µg/$446; 20 µg/$336; 1 mg/$1,460

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Human PLA2R / PLA2R1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G121979

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

152.81 kDa

Price:

100 µg/$710

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Mouse PLA2R / PLA2R1 Protein (Recombinant His-GST-S) (aa1418-1487) - LS-G25377

Source:

E. coli

Tag:

His-GST-S

Molecular Weight:

38.0 kDa

Price:

10 µg/$287; 50 µg/$480; 100 µg/$767; 200 µg/$957; 1 mg/$2,089; 500 µg/$1,617; 5 mg/$3,347; 2 mg/$2,278

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Human PLA2R / PLA2R1 Protein (Recombinant His) (aa395-530) - LS-G21692

Source:

E. coli

Tag:

His

Molecular Weight:

19.6 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human PLA2R / PLA2R1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67865

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

150.3 kDa

Price:

20 µg/$1,107

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Human PLA2R / PLA2R1 Protein (Recombinant 6His, N-terminus) (aa395-530) - LS-G57070

Source:

Mammalian Cells

Tag:

6His, N-terminus

Price:

100 µg/$1,009; 20 µg/$431; 1 mg/$3,451

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Human PLA2R / PLA2R1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80869

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

152.81 kDa

Price:

20 µg/$215

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