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Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F-actin polymerization at the pseudopods.Isoform ankyrin-iPLA2-1 and isoform ankyrin-iPLA2-2, which lack the catalytic domain, are probably involved in the negative regulation of iPLA2 activity.
Gene Name: | phospholipase A2, group VI (cytosolic, calcium-independent) |
Family/Subfamily: | Phospholipase , not assigned-Phospholipase |
Synonyms: | PLA2G6, Group VI phospholipase A2, IPLA2beta, IPLA2-VIA, INAD1, NBIA2, NBIA2A, NBIA2B, PNPLA9, CaI-PLA2, GVI, GVI PLA2, IPLA2, PARK14, PLA2 |
Target Sequences: | NM_003560 NP_003551.2 O60733 |
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