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PLA2G1B is a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response.
Gene Name: | phospholipase A2, group IB (pancreas) |
Family/Subfamily: | Phospholipase , not assigned-Phospholipase |
Synonyms: | PLA2G1B, Group IB phospholipase A2, Phospholipase A2, PLA2A, PPLA2, PLA2 |
Target Sequences: | NM_000928 NP_000919.1 P04054 |
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