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Homeodomain proteins are sequence-specific transcription factors that share a highly conserved DNA-binding domain and play fundamental roles in cell proliferation, differentiation, and death. PKNOX2 belongs to the TALE (3-amino acid loop extension) class of homeodomain proteins characterized by a 3-amino acid extension between alpha helices 1 and 2 within the homeodomain (Imoto et al., 2001 [PubMed 11549286]).[supplied by OMIM, Oct 2009]
Gene Name: | PBX/knotted 1 homeobox 2 |
Synonyms: | PKNOX2, Homeobox protein PKNOX2, Homeobox protein PREP-2, PBX/knotted 1 homeobox 2, PBX/knotted homeobox 2, PREP2 |
Target Sequences: | NM_022062 NP_071345.2 Q96KN3 |
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