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Pore-forming subunit of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD1L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect.
Gene Name: | polycystic kidney disease 2-like 1 |
Family/Subfamily: | Ion Channel , Calcium channel - TRP |
Synonyms: | PKD2L1, PCL, Polycystin-2 homolog, PKD2L, Polycystin-L, PKDL, Polycystin-L1, TRPP3, Polycystin-2L1 |
Target Sequences: | NM_016112 NP_057196.2 Q9P0L9 |
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