PKD1 / Polycystin

polycystic kidney disease 1 (autosomal dominant)

PKD1 / Polycystin is a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene. Also, six pseudogenes, closely linked in a known duplicated region on chromosome 16p, have been described.

☰ Filters

Products

Proteins (1)

Type

Recombinant (1)

Target

PKD1 / Polycystin (1)

Publications

No (1)

Tag

GST, N-terminus (1)

Species

Human (1)

Source

Wheat Germ Extract (1)

Select

Human PKD1 / Polycystin Protein (Recombinant GST, N-terminus) (aa730-829) - LS-G135955

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Molecular Weight:

36.74 kDa

Price:

10 µg/$479; 25 µg/$670

Viewing 1-1 of 1 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: Proteins

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.