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PKD1 / Polycystin

polycystic kidney disease 1 (autosomal dominant)

PKD1 / Polycystin is a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene. Also, six pseudogenes, closely linked in a known duplicated region on chromosome 16p, have been described.

Gene Name: polycystic kidney disease 1 (autosomal dominant)
Synonyms: PKD1, PBP, Polycystin, TRPP1, Pc-1, Polycystin 1, Polycystin-1
Target Sequences: NM_000296 NP_000287.3 P98161

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Proteins (1)
Recombinant (1)
PKD1 / Polycystin (1)
No (1)
GST, N-terminus (1)
Human (1)
Wheat Germ Extract (1)
PKD1 / Polycystin Protein - 12.5% SDS-PAGE Stained with Coomassie Blue
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Wheat Germ Extract
GST, N-terminus
36.74 kDa
10 µg/$479; 25 µg/$670
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).