PIWIL2

piwi-like RNA-mediated gene silencing 2

Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells. Its presence in oocytes suggests that it may participate in similar functions during oogenesis in females. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Associates with primary piRNAs in the cytoplasm and is required for PIWIL4/MIWI2 nuclear localization and association with secondary piRNAs antisense. The piRNA process acts upstream of known mediators of DNA methylation. Participates in a piRNA amplification loop. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Indirectly modulate expression of genes such as PDGFRB, SLC2A1, ITGA6, GJA7, THY1, CD9 and STRA8. Inhibits tumor cell growth when repressed. When overexpressed, acts as an oncogene by inhibition of apoptosis and promotion of proliferation in tumors.

☰ Filters

Products

Proteins (4)

Type

Over-Expression Lysate (4)

Target

PIWIL2 (4)

Publications

No (4)

Tag

Myc-DDK (Flag) (4)

Species

Human (2)

Source

293T Cells (2)

HEK 293 Cells (2)

Select

PIWIL2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G125525

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

109.7 kDa

Price:

100 µg/$710

Select

Human PIWIL2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G90784

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

109.7 kDa

Price:

20 µg/$215

Select

Human PIWIL2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G90785

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

109.7 kDa

Price:

20 µg/$150

Select

PIWIL2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101528

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

109.7 kDa

Price:

100 µg/$494

Viewing 1-4 of 4 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: Proteins

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.