PIP5K1A

phosphatidylinositol-4-phosphate 5-kinase, type I, alpha

Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organization, cell adhesion, migration and phagocytosis. Required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of RAC1 to the plasma membrane. Together with PIP5K1C is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle ingestion by activating WAS that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup. Together with PIP5K1B is required after stimulation of G-protein coupled receptors for stable platelet adhesion. Plays a role during calcium-induced keratinocyte differentiation. Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, diacylglycerol and inositol 1,4,5-trisphosphate that mobilize internal calcium and drive keratinocyte differentiation. Together with PIP5K1C have a role during embryogenesis. Functions also in the nucleus where acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs.

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Proteins (9)

Type

Over-Expression Lysate (6)

Recombinant (3)

Target

PIP5K1A (9)

Publications

No (9)

Tag

GST (1)

GST, N-terminus (2)

Myc-DDK (Flag) (6)

Species

Human (6)

Source

293T Cells (3)

HEK 293 Cells (3)

Wheat Germ Extract (3)

Purification

Purified (1)

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Human PIP5K1A Protein (Recombinant GST, N-terminus) (aa258-347) - LS-G60704

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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PIP5K1A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G125482

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

57.9 kDa

Price:

100 µg/$494

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PIP5K1A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G125484

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

62.5 kDa

Price:

100 µg/$494

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PIP5K1A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117256

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

61 kDa

Price:

100 µg/$710

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Human PIP5K1A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81824

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

57.9 kDa

Price:

20 µg/$150

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Human PIP5K1A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81826

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

61 kDa

Price:

20 µg/$215

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Human PIP5K1A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81825

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

62.5 kDa

Price:

20 µg/$150

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Human PIP5K1A Protein (Recombinant GST, N-terminus) (Full Length) - LS-G135926

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Molecular Weight:

121.4 kDa

Price:

10 µg/$479; 25 µg/$670

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Human PIP5K1A Protein (Recombinant GST) (Full Length) - LS-G31129

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

82.5 kDa

Price:

10 µg/$479; 25 µg/$670

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