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Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found.
Gene Name: | phosphoinositide-3-kinase, regulatory subunit 5 |
Synonyms: | PIK3R5, FOAP-2, PtdIns-3-kinase p101, p101-PI3K, PI3-kinase p101 subunit, Protein FOAP-2, p101 |
Target Sequences: | NM_014308 NP_055123.2 Q8WYR1 |
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