PIK3CA / PI3K Alpha

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation in breast cancer cells through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. Has also serine-protein kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), EIF4EBP1 and HRAS.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

PIK3CA / PI3K Alpha (5)

Publications

No (5)

Tag

GST, N-terminus (1)

His (1)

His, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (4)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Low Endotoxin Level

Low endotoxin level (1)

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Human PIK3CA / PI3K Alpha Protein (Recombinant GST, N-terminus) (aa959-1068) - LS-G59605

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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PIK3CA / PI3K Alpha Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115460

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

124.7 kDa

Price:

100 µg/$710

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Human PIK3CA / PI3K Alpha Protein (Recombinant His, N-terminus) - LS-G145971

Source:

E. coli

Tag:

His, N-terminus

Molecular Weight:

23.1 kDa

Price:

20 µg/$270; 100 µg/$390

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Human PIK3CA / PI3K Alpha Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77998

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

124.7 kDa

Price:

20 µg/$215

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Human PIK3CA / PI3K Alpha Protein (Recombinant His) (aa520-730) - LS-G141184

Source:

E. coli

Sequence Length:

210 AA

Tag:

His

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

23.21 kDa

Price:

10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531

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